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交错实施设计中的高效估计AI 解读

We study estimation of causal effects in staggered rollout designs, i.e. settings where there is staggered treatment adoption and the timing of treatment is as-good-as randomly assigned. We derive the most efficient estimator in a class of estimators that nests several popular generalized difference-in-differences methods. A feasible plug-in version of the efficient estimator is asymptotically unbiased with efficiency (weakly) dominating that of existing approaches. We…

医学应用中的回归不连续设计指南AI 解读

We present a practical guide for the analysis of regression discontinuity (RD) designs in biomedical contexts. We begin by introducing key concepts, assumptions, and estimands within both the continuity-based framework and the local randomization framework. We then discuss modern estimation and inference methods within both frameworks, including approaches for bandwidth or local neighborhood selection, optimal treatment effect point estimation, and robust bias-corrected…

高维动态处理效应的统计推断AI 解读

Estimating dynamic treatment effects is a crucial endeavor in causal inference, particularly when confronted with high-dimensional confounders. Doubly robust (DR) approaches have emerged as promising tools for estimating treatment effects due to their flexibility. However, we showcase that the traditional DR approaches that only focus on the DR representation of the expected outcomes may fall short of delivering optimal results. In this paper, we propose a novel DR…

Myerson 正则性约束下的 Grenander 型密度估计AI 解读

This study presents a novel approach to the density estimation of private values from second-price auctions, diverging from the conventional use of smoothing-based estimators. We introduce a Grenander-type estimator, constructed based on a shape restriction in the form of a convexity constraint. This constraint corresponds to the renowned Myerson regularity condition in auction theory, which is equivalent to the concavity of the revenue function for selling the auction item.…

混合试验中利用外部对照的因果推断框架AI 解读

We consider the challenges associated with causal inference in settings where data from a randomized trial is augmented with control data from an external source to improve efficiency in estimating the average treatment effect (ATE). Through the development of a formal causal inference framework, we outline sufficient causal assumptions about the exchangeability between the internal and external controls to identify the ATE and establish the connection to a novel graphical…

协变量自适应随机化下平均处理效应的半参数有效估计AI 解读

Experiments that use covariate adaptive randomization (CAR) are commonplace in applied economics and other fields. In such experiments, the experimenter first stratifies the sample according to observed baseline covariates and then assigns treatment randomly within these strata so as to achieve balance according to pre-specified stratum-specific target assignment proportions. In this paper, we compute the semiparametric efficiency bound for estimating the average treatment…

利用部分恢复的未测空间混杂变量改进双重稳健估计AI 解读

Studies in environmental and epidemiological sciences are often spatially varying and observational in nature with the aim of establishing cause and effect relationships. One of the major challenges with such studies is the presence of unmeasured spatial confounders. 'spatial confounding' is the phenomenon in which the spatial residuals are correlated to the spatial covariates in the model, when unaccounted for it can lead to biased causal effect estimates. This paper…

因果路线图在两项安全监测案例中的应用：电子病历协变量调整与结局预测AI 解读

Real-world data, such as administrative claims and electronic health records, are increasingly used for safety monitoring and to help guide regulatory decision-making. In these settings, it is important to document analytic decisions transparently and objectively to ensure that analyses meet their intended goals. The Causal Roadmap is an established framework that can guide and document analytic decisions through each step of the analytic pipeline, which will help…

不可忽略结局缺失与未测混杂下的因果推断AI 解读

Observational studies are the primary source of data for causal inference, but it is challenging when existing unmeasured confounding. Missing data problems are also common in observational studies. How to obtain the causal effects from the nonignorable missing data with unmeasured confounding is a challenge. In this paper, we consider that how to obtain complier average causal effect with unmeasured confounding from the nonignorable missing outcomes. We propose an auxiliary…

样本选择下的分布差异分解与性别工资差距AI 解读

I address the decomposition of the differences between the distribution of outcomes of two groups when individuals self-select themselves into participation. I differentiate between the decomposition for participants and the entire population, highlighting how the primitive components of the model affect each of the distributions of outcomes. Additionally, I introduce two ancillary decompositions that help uncover the sources of differences in the distribution of…

缺失数据模型的贝叶斯敏感性分析AI 解读

In causal inference, sensitivity analysis is important to assess the robustness of study conclusions to key assumptions. We perform sensitivity analysis of the assumption that missing outcomes are missing completely at random. We follow a Bayesian approach, which is nonparametric for the outcome distribution and can be combined with an informative prior on the sensitivity parameter. We give insight in the posterior and provide theoretical guarantees in the form of…

重复事件数据因果中介分析的稳健推断AI 解读

Recurrent events, including cardiovascular events, are commonly observed in biomedical studies. Researchers must understand the effects of various treatments on recurrent events and investigate the underlying mediation mechanisms by which treatments may reduce the frequency of recurrent events are crucial. Although causal inference methods for recurrent event data have been proposed, they cannot be used to assess mediation. This study proposed a novel methodology of causal…

关注收入差距：小样本不平等估计量的偏差校正AI 解读

Income inequality estimators are biased in small samples, leading generally to an underestimation. This aspect deserves particular attention when estimating inequality in small domains and performing small area estimation at the area level. We propose a bias correction framework for a large class of inequality measures comprising the Gini Index, the Generalized Entropy and the Atkinson index families by accounting for complex survey designs. The proposed methodology does not…

分层随机实验与匹配观测研究中的个体处理效应分位数AI 解读

Evaluating the treatment effects has become an important topic for many applications. However, most existing literature focuses mainly on the average treatment effects. When the individual effects are heavy-tailed or have outlier values, not only may the average effect not be appropriate for summarizing the treatment effects, but also the conventional inference for it can be sensitive and possibly invalid due to poor large-sample approximations. In this paper we focus on…

条件平均处理效应的近端因果学习AI 解读

Efficiently and flexibly estimating treatment effect heterogeneity is an important task in a wide variety of settings ranging from medicine to marketing, and there are a considerable number of promising conditional average treatment effect estimators currently available. These, however, typically rely on the assumption that the measured covariates are enough to justify conditional exchangeability. We propose the P-learner, motivated by the R- and DR-learner, a tailored…

利用倾向得分加权进行调节效应分析：性少数成年人吸烟差异的应用教程AI 解读

Objective. To provide step-by-step guidance and STATA and R code for using propensity score (PS) weighting to estimate moderation effects. Research Design. Tutorial illustrating the key steps for estimating and testing moderation using observational data. Steps include (1) examining covariate overlap across treatment groups within levels of the moderator, (2) estimating the PS weights, (3) evaluating whether PS weights improved covariate balance, (4) estimating moderated…

序贯可忽略性下部分可观测马尔可夫决策过程的离策略评估AI 解读

We consider off-policy evaluation of dynamic treatment rules under sequential ignorability, given an assumption that the underlying system can be modeled as a partially observed Markov decision process (POMDP). We propose an estimator, partial history importance weighting, and show that it can consistently estimate the stationary mean rewards of a target policy given long enough draws from the behavior policy. We provide an upper bound on its error that decays polynomially…

SECRETS：利用合成干预提高随机临床试验的受试者效率AI 解读

The randomized controlled trial (RCT) is the gold standard for estimating the average treatment effect (ATE) of a medical intervention but requires 100s-1000s of subjects, making it expensive and difficult to implement. While a cross-over trial can reduce sample size requirements by measuring the treatment effect per individual, it is only applicable to chronic conditions and interventions whose effects dissipate rapidly. Another approach is to replace or augment data…

通过高效数据聚合估计处理效应AI 解读

Data aggregation, also known as meta analysis, is widely used to combine knowledge on parameters shared in common (e.g., average treatment effect) between multiple studies. In this paper, we introduce an attractive data aggregation scheme that pools summary statistics from various existing studies. Our scheme informs the design of new validation studies and yields us unbiased estimators for the shared parameters. In our setup, each existing study applies a LASSO regression…

存在处理后混杂变量时因果中介分析的贝叶斯非参数方法AI 解读

We propose a new Bayesian non-parametric (BNP) method for estimating the causal effects of mediation in the presence of a post-treatment confounder. We specify an enriched Dirichlet process mixture (EDPM) to model the joint distribution of the observed data (outcome, mediator, post-treatment confounders, treatment, and baseline confounders). The proposed BNP model allows more confounder-based clusters than clusters for the outcome and mediator. For identifiability, we use…

用于构建临床试验合成对照组的贝叶斯非参数共同原子回归AI 解读

The availability of electronic health records (EHR) has opened opportunities to supplement increasingly expensive and difficult to carry out randomized controlled trials (RCT) with evidence from readily available real world data. In this paper, we use EHR data to construct synthetic control arms for treatment-only single arm trials. We propose a novel nonparametric Bayesian common atoms mixture model that allows us to find equivalent population strata in the EHR and the…

利用阶段变量发现健康时间序列中的因果关系AI 解读

Using observational data to learn causal relationships is essential when randomized experiments are not possible, such as in healthcare. Discovering causal relationships in time-series health data is even more challenging when relationships change over the course of a disease, such as medications that are most effective early on or for individuals with severe disease. Stage variables such as weeks of pregnancy, disease stages, or biomarkers like HbA1c, can influence what…

利用三重代理变量控制潜在混杂AI 解读

We present new results for nonparametric identification of causal effects using noisy proxies for unobserved confounders. Our approach builds on the results of \citet{Hu2008} who tackle the problem of general measurement error. We call this the `triple proxy' approach because it requires three proxies that are jointly independent conditional on unobservables. We consider three different choices for the third proxy: it may be an outcome, a vector of treatments, or a…

校正实验中的干扰：抖音案例研究AI 解读

Interference is a ubiquitous problem in experiments conducted on two-sided content marketplaces, such as Douyin (China's analog of TikTok). In many cases, creators are the natural unit of experimentation, but creators interfere with each other through competition for viewers' limited time and attention. "Naive" estimators currently used in practice simply ignore the interference, but in doing so incur bias on the order of the treatment effect. We formalize the problem of…