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TAD-SIE：结合趋势自适应设计与合成干预估计的随机临床试验样本量确定AI 解读

Phase-3 clinical trials provide the highest level of evidence on drug safety and effectiveness needed for market approval by implementing large randomized controlled trials (RCTs). However, 30-40% of these trials fail mainly because such studies have inadequate sample sizes, stemming from the inability to obtain accurate initial estimates of average treatment effect parameters. To remove this obstacle from the drug development cycle, we present a new algorithm called…

非参数结构函数与弹性的自适应估计及一致置信带AI 解读

We introduce two data-driven procedures for optimal estimation and inference in nonparametric models using instrumental variables. The first is a data-driven choice of sieve dimension for a popular class of sieve two-stage least squares estimators. When implemented with this choice, estimators of both the structural function $h_0$ and its derivatives (such as elasticities) converge at the fastest possible (i.e., minimax) rates in sup-norm. The second is for constructing…

论 Rosenbaum 基于秩的匹配估计量AI 解读

In two influential contributions, Rosenbaum (2005, 2020) advocated for using the distances between component-wise ranks, instead of the original data values, to measure covariate similarity when constructing matching estimators of average treatment effects. While the intuitive benefits of using covariate ranks for matching estimation are apparent, there is no theoretical understanding of such procedures in the literature. We fill this gap by demonstrating that Rosenbaum's…

因子模型中的反事实AI 解读

We study a new model where the potential outcomes, corresponding to the values of a (possibly continuous) treatment, are linked through common factors. The factors can be estimated using a panel of regressors. We propose a procedure to estimate time-specific and unit-specific average marginal effects in this context. Our approach can be used either with high-dimensional time series or with large panels. It allows for treatment effects heterogenous across time and units and…

ddml：在 Stata 中实施双重／去偏机器学习AI 解读

We introduce the package ddml for Double/Debiased Machine Learning (DDML) in Stata. Estimators of causal parameters for five different econometric models are supported, allowing for flexible estimation of causal effects of endogenous variables in settings with unknown functional forms and/or many exogenous variables. ddml is compatible with many existing supervised machine learning programs in Stata. We recommend using DDML in combination with stacking estimation which…

边存在依赖时网络效应的最优非参数推断AI 解读

Testing network effects in weighted directed networks is a foundational problem in econometrics, sociology, and psychology. Yet, the prevalent edge dependency poses a significant methodological challenge. Most existing methods are model-based and come with stringent assumptions, limiting their applicability. In response, we introduce a novel, fully nonparametric framework that requires only minimal regularity assumptions. While inspired by recent developments in $U$-statistic…

Dagma-DCE：可解释的非参数可微因果发现AI 解读

We introduce Dagma-DCE, an interpretable and model-agnostic scheme for differentiable causal discovery. Current non- or over-parametric methods in differentiable causal discovery use opaque proxies of ``independence'' to justify the inclusion or exclusion of a causal relationship. We show theoretically and empirically that these proxies may be arbitrarily different than the actual causal strength. Juxtaposed to existing differentiable causal discovery algorithms,…

对弱工具变量或无效工具变量的稳健性：利用机器学习探索非线性治疗模型AI 解读

We discuss causal inference for observational studies with possibly invalid instrumental variables. We propose a novel methodology called two-stage curvature identification (TSCI) by exploring the nonlinear treatment model with machine learning. {The first-stage machine learning enables improving the instrumental variable's strength and adjusting for different forms of violating the instrumental variable assumptions.} The success of TSCI requires the instrumental variable's…

跨数据孤岛的因果效应解耦估计AI 解读

Estimating causal effects among different events is of great importance to critical fields such as drug development. Nevertheless, the data features associated with events may be distributed across various silos and remain private within respective parties, impeding direct information exchange between them. This, in turn, can result in biased estimations of local causal effects, which rely on the characteristics of only a subset of the covariates. To tackle this challenge,…

路边上下客拥堵效应的估计与缓解：因果推断方法AI 解读

Curb space is one of the busiest areas in urban road networks. Especially in recent years, the rapid increase of ride-hailing trips and commercial deliveries has induced massive pick-ups/drop-offs (PUDOs), which occupy the limited curb space that was designed and built decades ago. These PUDOs could jam curbside utilization and disturb the mainline traffic flow, evidently leading to significant negative societal externalities. However, there is a lack of an analytical…

用于因果效应估计的迁移学习AI 解读

We present a Transfer Causal Learning (TCL) framework when target and source domains share the same covariate/feature spaces, aiming to improve causal effect estimation accuracy in limited data. Limited data is very common in medical applications, where some rare medical conditions, such as sepsis, are of interest. Our proposed method, named \texttt{$\ell_1$-TCL}, incorporates $\ell_1$ regularized TL for nuisance models (e.g., propensity score model); the TL estimator of the…

因果研究的方法、挑战与前景综述AI 解读

Deep Learning models have shown success in a large variety of tasks by extracting correlation patterns from high-dimensional data but still struggle when generalizing out of their initial distribution. As causal engines aim to learn mechanisms independent from a data distribution, combining Deep Learning with Causality can have a great impact on the two fields. In this paper, we further motivate this assumption. We perform an extensive overview of the theories and methods…

纵向数据与死亡截断下的贝叶斯主分层AI 解读

In many causal studies, outcomes are censored by death, in the sense that they are neither observed nor defined for units who die. In such studies, the focus is usually on the stratum of always survivors up to a single fixed time s. Building on a recent strand of the literature, we propose an extended framework for the analysis of longitudinal studies, where units can die at different time points, and the main endpoints are observed and well defined only up to the death…

通过条件分位数回归估计无条件分位数偏效应AI 解读

This paper develops a semi-parametric procedure for estimation of unconditional quantile partial effects using quantile regression coefficients. The estimator is based on an identification result showing that, for continuous covariates, unconditional quantile effects are a weighted average of conditional ones at particular quantile levels that depend on the covariates. We propose a two-step estimator for the unconditional effects where in the first step one estimates a…

面板模型的稳健推断：小样本异方差与高杠杆观测的影响AI 解读

With the violation of the assumption of homoskedasticity, least squares estimators of the variance become inefficient and statistical inference conducted with invalid standard errors leads to misleading rejection rates. Despite a vast cross-sectional literature on the downward bias of robust standard errors, the problem is not extensively covered in the panel data framework. We investigate the consequences of the simultaneous presence of small sample size, heteroskedasticity…

用于品牌评估的消费者选择模型AI 解读

Consumer choice modeling takes center stage as we delve into understanding how personal preferences of decision makers (customers) for products influence demand at the level of the individual. The contemporary choice theory is built upon the characteristics of the decision maker, alternatives available for the choice of the decision maker, the attributes of the available alternatives and decision rules that the decision maker uses to make a choice. The choice set in our…

断点的设计：从断点回归到最优分区AI 解读

Discontinuities can be fairly arbitrary but also cause a significant impact on outcomes in larger systems. Indeed, their arbitrariness is why they have been used to infer causal relationships among variables in numerous settings. Regression discontinuity from econometrics assumes the existence of a discontinuous variable that splits the population into distinct partitions to estimate the causal effects of a given phenomenon. Here we consider the design of partitions for a…

通过校准处理抵抗人群的方差推断存在混杂的处理效应AI 解读

In a general set-up that allows unmeasured confounding, we show that the conditional average treatment effect on the treated can be identified as one of two possible values. Unlike existing causal inference methods, we do not require an exogenous source of variability in the treatment, e.g., an instrument or another outcome unaffected by the treatment. Instead, we require (a) a nondeterministic treatment assignment, (b) that conditional variances of the two potential…

协变量自适应最小化随机分配下分层不平衡协方差的一致估计AI 解读

Pocock and Simon's minimization method is a popular approach for covariate-adaptive randomization in clinical trials. Valid statistical inference with data collected under the minimization method requires the knowledge of the limiting covariance matrix of within-stratum imbalances, whose existence is only recently established. In this work, we propose a bootstrap-based estimator for this limit and establish its consistency, in particular, by Le Cam's third lemma. As an…

因果森林对流形数据结构的自适应AI 解读

Researchers often hold the belief that random forests are "the cure to the world's ills" (Bickel, 2010). But how exactly do they achieve this? Focused on the recently introduced causal forests (Athey and Imbens, 2016; Wager and Athey, 2018), this manuscript aims to contribute to an ongoing research trend towards answering this question, proving that causal forests can adapt to the unknown covariate manifold structure. In particular, our analysis shows that a causal forest…

具有情境价格弹性与异方差估值的动态定价AI 解读

We study an online contextual dynamic pricing problem, where customers decide whether to purchase a product based on its features and price. We introduce a novel approach to modeling a customer's expected demand by incorporating feature-based price elasticity, which can be equivalently represented as a valuation with heteroscedastic noise. To solve the problem, we propose a computationally efficient algorithm called "Pricing with Perturbation (PwP)", which enjoys an $O(\sqrt{dT\log T})$…

基于经验动态建模的因果检测综述AI 解读

In contemporary scientific research, understanding the distinction between correlation and causation is crucial. While correlation is a widely used analytical standard, it does not inherently imply causation. This paper addresses the potential for misinterpretation in relying solely on correlation, especially in the context of nonlinear dynamics. Despite the rapid development of various correlation research methodologies, including machine learning, the exploration into…

不可观测因素选择下合成控制法的大样本性质AI 解读

We analyze the synthetic control (SC) method in panel data settings with many units. We assume the treatment assignment is based on unobserved heterogeneity and pre-treatment information, allowing for both strictly and sequentially exogenous assignment processes. We show that the critical property that determines the behavior of the SC method is the ability of input features to approximate the unobserved heterogeneity. Our results imply that the SC method delivers…

干扰结构设定的随机化检验AI 解读

This study considers testing the specification of spillover effects in causal inference. We focus on experimental settings in which the treatment assignment mechanism is known to researchers. We develop a new randomization test utilizing a hierarchical relationship between different exposures. Compared with existing approaches, our approach is essentially applicable to any null exposure specifications and produces powerful test statistics without a priori knowledge of the…