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High-dimensional Factor Analysis for Network-linked Data

网络关联数据的高维因子分析

Factor analysis is a widely used statistical tool in many scientific disciplines, such as psychology, economics, and sociology. As observations linked by networks become increasingly common, incorporating network structures into factor analysis remains an open problem. In this paper, we focus on high-dimensional factor analysis involving network-connected observations, and propose a generalized factor model with latent factors that account for both the network structure and…

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Covariate-adjusted Group Sequential Comparisons of Survival Probabilities

协变量调整的生存概率组序贯比较

In confirmatory clinical trials, survival outcomes are frequently studied and interim analyses for efficacy and/or futility are often desirable. Methods such as the log rank test and Cox regression model are commonly used to compare treatments in this setting. They rely on a proportional hazards (PH) assumption and are subject to type I error rate inflation and loss of power when PH are violated. Such violations may be expected a priori, particularly when the mechanisms of…

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Resistant Inference in Instrumental Variable Models

工具变量模型中的抗污染推断

The classical tests in the instrumental variable model can behave arbitrarily if the data is contaminated. For instance, one outlying observation can be enough to change the outcome of a test. We develop a framework to construct testing procedures that are robust to weak instruments, outliers and heavy-tailed errors in the instrumental variable model. The framework is constructed upon M-estimators. By deriving the influence functions of the classical weak instrument robust…

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Sample Empirical Likelihood Methods for Causal Inference

用于因果推断的样本经验似然方法

Causal inference is crucial for understanding the true impact of interventions, policies, or actions, enabling informed decision-making and providing insights into the underlying mechanisms that shape our world. In this paper, we establish a framework for the estimation and inference of average treatment effects using a two-sample empirical likelihood function. Two different approaches to incorporating propensity scores are developed. The first approach introduces propensity…

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Uncertainty Quantification of MLE for Entity Ranking with Covariates

带协变量的实体排序:极大似然估计的不确定性量化

This paper concerns with statistical estimation and inference for the ranking problems based on pairwise comparisons with additional covariate information such as the attributes of the compared items. Despite extensive studies, few prior literatures investigate this problem under the more realistic setting where covariate information exists. To tackle this issue, we propose a novel model, Covariate-Assisted Ranking Estimation (CARE) model, that extends the well-known…

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The Informativeness of Combined Experimental and Observational Data under Dynamic Selection

动态选择下实验与观察数据结合的信息含量

This paper addresses the challenge of estimating the Average Treatment Effect on the Treated Survivors (ATETS; Vikstrom et al., 2018) in the absence of long-term experimental data, utilizing available long-term observational data instead. We establish two theoretical results. First, it is impossible to obtain informative bounds for the ATETS with no model restriction and no auxiliary data. Second, to overturn this negative result, we explore as a promising avenue the recent…

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Learning Directed Acyclic Graphs from Partial Orderings

利用部分因果排序学习有向无环图

Directed acyclic graphs (DAGs) are commonly used to model causal relationships among random variables. In general, learning the DAG structure is both computationally and statistically challenging. Moreover, without additional information, the direction of edges may not be estimable from observational data. In contrast, given a complete causal ordering of the variables, the problem can be solved efficiently, even in high dimensions. In this paper, we consider the intermediate…

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Optimized Model Selection for Estimating Treatment Effects from Costly Simulations of the US Opioid Epidemic

美国阿片类药物流行高成本模拟中的处理效应估计模型选择

Agent-based simulation with a synthetic population can help us compare different treatment conditions while keeping everything else constant within the same population (i.e., as digital twins). Such population-scale simulations require large computational power (i.e., CPU resources) to get accurate estimates for treatment effects. We can use meta models of the simulation results to circumvent the need to simulate every treatment condition. Selecting the best estimating model…

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Distribution-consistency Structural Causal Models

分布一致性结构因果模型

In the field of causal modeling, potential outcomes (PO) and structural causal models (SCMs) stand as the predominant frameworks. However, these frameworks face notable challenges in practically modeling counterfactuals, formalized as parameters of the joint distribution of potential outcomes. Counterfactual reasoning holds paramount importance in contemporary decision-making processes, especially in scenarios that demand personalized incentives based on the joint values of $(Y(0), Y(1))$…

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Identifying Linearly-Mixed Causal Representations from Multi-Node Interventions

从多节点干预识别线性混合的因果表示

The task of inferring high-level causal variables from low-level observations, commonly referred to as causal representation learning, is fundamentally underconstrained. As such, recent works to address this problem focus on various assumptions that lead to identifiability of the underlying latent causal variables. A large corpus of these preceding approaches consider multi-environment data collected under different interventions on the causal model. What is common to…

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Tests for almost stochastic dominance

近似随机占优检验

We introduce a 2-dimensional stochastic dominance (2DSD) index to characterize both strict and almost stochastic dominance. Based on this index, we derive an estimator for the minimum violation ratio (MVR), also known as the critical parameter, of the almost stochastic ordering condition between two variables. We determine the asymptotic properties of the empirical 2DSD index and MVR for the most frequently used stochastic orders. We also provide conditions under which the…

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Single Proxy Control

单代理混杂控制

Negative control variables are sometimes used in non-experimental studies to detect the presence of confounding by hidden factors. A negative control outcome (NCO) is an outcome that is influenced by unobserved confounders of the exposure effects on the outcome in view, but is not causally impacted by the exposure. Tchetgen Tchetgen (2013) introduced the Control Outcome Calibration Approach (COCA) as a formal NCO counterfactual method to detect and correct for residual…

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A Causal Analysis of CO2 Reduction Strategies in Electricity Markets Through Machine Learning-Driven Metalearners

基于机器学习元学习器的电力市场减排策略因果分析

This study employs the Causal Machine Learning (CausalML) statistical method to analyze the influence of electricity pricing policies on carbon dioxide (CO2) levels in the household sector. Investigating the causality between potential outcomes and treatment effects, where changes in pricing policies are the treatment, our analysis challenges the conventional wisdom surrounding incentive-based electricity pricing. The study's findings suggest that adopting such policies may…

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A Transfer Learning Causal Approach to Evaluate Racial/Ethnic and Geographic Variation in Outcomes Following Congenital Heart Surgery

迁移学习因果方法:先天性心脏手术结局的族裔与地区差异

Congenital heart defects (CHD) are the most prevalent birth defects in the United States and surgical outcomes vary considerably across the country. The outcomes of treatment for CHD differ for specific patient subgroups, with non-Hispanic Black and Hispanic populations experiencing higher rates of mortality and morbidity. A valid comparison of outcomes within racial/ethnic subgroups is difficult given large differences in case-mix and small subgroup sizes. We propose a…

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Interpretable Causal Inference for Analyzing Wearable, Sensor, and Distributional Data

可穿戴设备、传感器与分布型数据的可解释因果推断

Many modern causal questions ask how treatments affect complex outcomes that are measured using wearable devices and sensors. Current analysis approaches require summarizing these data into scalar statistics (e.g., the mean), but these summaries can be misleading. For example, disparate distributions can have the same means, variances, and other statistics. Researchers can overcome the loss of information by instead representing the data as distributions. We develop an…

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Forster-Warmuth Counterfactual Regression: A Unified Learning Approach

Forster–Warmuth 反事实回归:统一学习方法

Series or orthogonal basis regression is one of the most popular non-parametric regression techniques in practice, obtained by regressing the response on features generated by evaluating the basis functions at observed covariate values. The most routinely used series estimator is based on ordinary least squares fitting, which is known to be minimax rate optimal in various settings, albeit under stringent restrictions on the basis functions and the distribution of covariates.…

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Data integration methods for micro-randomized trials

微随机试验的数据整合方法

Existing statistical methods for the analysis of micro-randomized trials (MRTs) are designed to estimate causal excursion effects using data from a single MRT. In practice, however, researchers can often find previous MRTs that employ similar interventions. In this paper, we develop data integration methods that capitalize on this additional information, leading to statistical efficiency gains. To further increase efficiency, we demonstrate how to combine these approaches…

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Robust Inference in Locally Misspecified Bipartite Networks

局部误设双部网络中的稳健推断

This paper introduces a methodology to conduct robust inference in bipartite networks under local misspecification. We focus on a class of dyadic network models with misspecified conditional moment restrictions. The framework of misspecification is local, as the effect of misspecification varies with the sample size. We utilize this local asymptotic approach to construct a robust estimator that is minimax optimal for the mean square error within a neighborhood of…

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Bayesian Nonparametric Trees for Principal Causal Effects

用于主分层因果效应的贝叶斯非参数树模型

Principal stratification analysis evaluates how causal effects of a treatment on a primary outcome vary across strata of units defined by their treatment effect on some intermediate quantity. This endeavor is substantially challenged when the intermediate variable is continuously scaled and there are infinitely many basic principal strata. We employ a Bayesian nonparametric approach to flexibly evaluate treatment effects across flexibly-modeled principal strata. The approach…

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Causal Change Point Detection and Localization

因果变化点的检测与定位

Detecting and localizing change points in sequential data is of interest in many areas of application. Various notions of change points have been proposed, such as changes in mean, variance, or the linear regression coefficient. In this work, we consider settings in which a response variable $Y$ and a set of covariates $X=(X^1,\ldots,X^{d+1})$ are observed over time and aim to find changes in the causal mechanism generating $Y$ from $X$. More specifically, we assume $Y$ depen…

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Foundations of Causal Discovery on Groups of Variables

变量组因果发现的理论基础

Discovering causal relationships from observational data is a challenging task that relies on assumptions connecting statistical quantities to graphical or algebraic causal models. In this work, we focus on widely employed assumptions for causal discovery when objects of interest are (multivariate) groups of random variables rather than individual (univariate) random variables, as is the case in a variety of problems in scientific domains such as climate science or…

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A modified debiased inverse-variance weighted estimator in two-sample summary-data Mendelian randomization

两样本汇总数据孟德尔随机化中的修正去偏逆方差加权估计

Mendelian randomization uses genetic variants as instrumental variables to make causal inferences about the effects of modifiable risk factors on diseases from observational data. One of the major challenges in Mendelian randomization is that many genetic variants are only modestly or even weakly associated with the risk factor of interest, a setting known as many weak instruments. Many existing methods, such as the popular inverse-variance weighted (IVW) method, could be…

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ODE Discovery for Longitudinal Heterogeneous Treatment Effects Inference

用于纵向异质性处理效应推断的常微分方程发现

Inferring unbiased treatment effects has received widespread attention in the machine learning community. In recent years, our community has proposed numerous solutions in standard settings, high-dimensional treatment settings, and even longitudinal settings. While very diverse, the solution has mostly relied on neural networks for inference and simultaneous correction of assignment bias. New approaches typically build on top of previous approaches by proposing new (or…

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Assessing Delayed Treatment Benefits of Immunotherapy Using Long-Term Average Hazard: A Novel Test/Estimation Approach

用长期平均风险评估免疫治疗的延迟获益

Delayed treatment effects on time-to-event outcomes have often been observed in randomized controlled studies of cancer immunotherapies. In the case of delayed onset of treatment effect, the conventional test/estimation approach using the log-rank test for between-group comparison and Cox's hazard ratio to estimate the magnitude of treatment effect is not optimal, because the log-rank test is not the most powerful option, and the interpretation of the resulting hazard ratio…

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