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Comparing restricted mean survival times in small sample clinical trials using pseudo-observations

用伪观测比较小样本临床试验的限制平均生存时间

The widely used proportional hazard assumption cannot be assessed reliably in small-scale clinical trials and might often in fact be unjustified, e.g. due to delayed treatment effects. An alternative to the hazard ratio as effect measure is the difference in restricted mean survival time (RMST) that does not rely on model assumptions. Although an asymptotic test for two-sample comparisons of the RMST exists, it has been shown to suffer from an inflated type I error rate in…

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Differentially Private Estimation of Weighted Average Treatment Effects for Binary Outcomes

二元结果加权平均处理效应的差分隐私估计

In the social and health sciences, researchers often make causal inferences using sensitive variables. These researchers, as well as the data holders themselves, may be ethically and perhaps legally obligated to protect the confidentiality of study participants' data. It is now known that releasing any statistics, including estimates of causal effects, computed with confidential data leaks information about the underlying data values. Thus, analysts may desire to use causal…

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Adjusting for Incomplete Baseline Covariates in Randomized Controlled Trials: A Cross-World Imputation Framework

随机试验中不完整基线协变量的调整:跨世界插补框架

In randomized controlled trials, adjusting for baseline covariates is often applied to improve the precision of treatment effect estimation. However, missingness in covariates is common. Recently, Zhao & Ding (2022) studied two simple strategies, the single imputation method and missingness indicator method (MIM), to deal with missing covariates, and showed that both methods can provide efficiency gain. To better understand and compare these two strategies, we propose and…

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Effects Among the Affected

受影响者中的效应

Many interventions are both beneficial to initiate and harmful to stop. Traditionally, to determine whether to deploy that intervention in a time-limited way depends on if, on average, the increase in the benefits of starting it outweigh the increase in the harms of stopping it. We propose a novel causal estimand that provides a more nuanced understanding of the effects of such treatments, particularly, how response to an earlier treatment (e.g., treatment initiation)…

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Double/Debiased CoCoLASSO of Treatment Effects with Mismeasured High-Dimensional Control Variables

含测量误差的高维控制变量下处理效应的双重去偏 CoCoLASSO

We develop an estimator for treatment effects in high-dimensional settings with additive measurement error, a prevalent challenge in modern econometrics. We introduce the Double/Debiased Convex Conditioned LASSO (Double/Debiased CoCoLASSO), which extends the double/debiased machine learning framework to accommodate mismeasured covariates. Our principal contributions are threefold. (1) We construct a Neyman-orthogonal score function that remains valid under measurement error,…

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$\ell_1$-penalized Multinomial Regression: Estimation, inference, and prediction, with an application to risk factor identification for different dementia subtypes

ℓ1惩罚多项回归:估计、推断与预测及痴呆亚型风险因素识别

High-dimensional multinomial regression models are very useful in practice but have received less research attention than logistic regression models, especially from the perspective of statistical inference. In this work, we analyze the estimation and prediction error of the contrast-based $\ell_1$-penalized multinomial regression model and extend the debiasing method to the multinomial case, providing a valid confidence interval for each coefficient and $p$-value of the…

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Inference on Consensus Ranking of Distributions

分布共识排序的统计推断

Instead of testing for unanimous agreement, I propose learning how broad of a consensus favors one distribution over another (of earnings, productivity, asset returns, test scores, etc.). Specifically, given a sample from each of two distributions, I propose statistical inference methods to learn about the set of utility functions for which the first distribution has higher expected utility than the second distribution. With high probability, an "inner" confidence set is…

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Who Are We Missing? A Principled Approach to Characterizing the Underrepresented Population

我们遗漏了谁?识别代表性不足人群的系统方法

Randomized controlled trials (RCTs) serve as the cornerstone for understanding causal effects, yet extending inferences to target populations presents challenges due to effect heterogeneity and underrepresentation. Our paper addresses the critical issue of identifying and characterizing underrepresented subgroups in RCTs, proposing a novel framework for refining target populations to improve generalizability. We introduce an optimization-based approach, Rashomon Set of…

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Causal Estimation of Exposure Shifts with Neural Networks

利用神经网络估计暴露分布变化的因果效应

A fundamental task in causal inference is estimating the effect of distribution shift in the treatment variable. We refer to this problem as shift-response function (SRF) estimation. Existing neural network methods for causal inference lack theoretical guarantees and practical implementations for SRF estimation. In this paper, we introduce Targeted Regularization for Exposure Shifts with Neural Networks (TRESNET), a method to estimate SRFs with robustness and efficiency…

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Experimental Design For Causal Inference Through An Optimization Lens

从优化视角理解因果推断的实验设计

The study of experimental design offers tremendous benefits for answering causal questions across a wide range of applications, including agricultural experiments, clinical trials, industrial experiments, social experiments, and digital experiments. Although valuable in such applications, the costs of experiments often drive experimenters to seek more efficient designs. Recently, experimenters have started to examine such efficiency questions from an optimization…

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What if? Causal Machine Learning in Supply Chain Risk Management

如果改变会怎样?供应链风险管理中的因果机器学习

The penultimate goal for developing machine learning models in supply chain management is to make optimal interventions. However, most machine learning models identify correlations in data rather than inferring causation, making it difficult to systematically plan for better outcomes. In this article, we propose and evaluate the use of causal machine learning for developing supply chain risk intervention models, and demonstrate its use with a case study in supply chain risk…

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Combining observational and experimental data for causal inference considering data privacy

考虑数据隐私的观察性与实验数据融合因果推断

Combining observational and experimental data for causal inference can improve treatment effect estimation. However, many observational data sets cannot be released due to data privacy considerations, so one researcher may not have access to both experimental and observational data. Nonetheless, a small amount of risk of disclosing sensitive information might be tolerable to organizations that house confidential data. In these cases, organizations can employ data privacy…

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A latent space model for multivariate count data time series analysis

多变量计数时间序列分析的潜在空间模型

Motivated by a dataset of burglaries in Chicago, USA, we introduce a novel framework to analyze time series of count data combining common multivariate time series models with latent position network models. This novel methodology allows us to gain a new latent variable perspective on the crime dataset that we consider, allowing us to disentangle and explain the complex patterns exhibited by the data, while providing a natural time series framework that can be used to make…

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Fixed-b Asymptotics for Panel Models with Two-Way Clustering

双向聚类面板模型的固定 b 渐近理论

This paper studies a cluster robust variance estimator proposed by Chiang, Hansen and Sasaki (2024) for linear panels. First, we show algebraically that this variance estimator (CHS estimator, hereafter) is a linear combination of three common variance estimators: the one-way unit cluster estimator, the "HAC of averages" estimator, and the "average of HACs" estimator. Based on this finding, we obtain a fixed-$b$ asymptotic result for the CHS estimator and corresponding test…

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Revisiting Panel Data Discrete Choice Models with Lagged Dependent Variables

重新研究含滞后因变量的面板离散选择模型

This paper revisits the identification and estimation of a class of semiparametric (distribution-free) panel data binary choice models with lagged dependent variables, exogenous covariates, and entity fixed effects. We provide a novel identification strategy, using an "identification at infinity" argument. In contrast with the celebrated Honore and Kyriazidou (2000), our method permits time trends of any form and does not suffer from the "curse of dimensionality". We propose…

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Hidden Markov Models for Multivariate Panel Data

用于多变量面板数据的隐马尔可夫模型

While advances continue to be made in model-based clustering, challenges persist in modeling various data types such as panel data. Multivariate panel data present difficulties for clustering algorithms because they are often plagued by missing data and dropouts, presenting issues for estimation algorithms. This research presents a family of hidden Markov models that compensate for the issues that arise in panel data. A modified expectation-maximization algorithm capable of…

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Enhancing Causal Discovery in Financial Networks with Piecewise Quantile Regression

利用分段分位数回归改进金融网络中的因果发现

Financial networks can be constructed using statistical dependencies found within the price series of speculative assets. Across the various methods used to infer these networks, there is a general reliance on predictive modelling to capture cross-correlation effects. These methods usually model the flow of mean-response information, or the propagation of volatility and risk within the market. Such techniques, though insightful, don't fully capture the broader…

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$ρ$-GNF: A Copula-based Sensitivity Analysis to Unobserved Confounding Using Normalizing Flows

ρ-GNF:利用 Copula 与归一化流分析未观测混杂的敏感性

We propose a novel sensitivity analysis to unobserved confounding in observational studies using copulas and normalizing flows. Using the idea of interventional equivalence of structural causal models, we develop $ρ$-GNF ($ρ$-graphical normalizing flow), where $ρ{\in}[-1,+1]$ is a bounded sensitivity parameter. This parameter represents the back-door non-causal association due to unobserved confounding, and which is encoded with a Gaussian copula. In other words, the $ρ$-GNF…

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Estimating Treatment Effects using Multiple Surrogates: The Role of the Surrogate Score and the Surrogate Index

利用多个替代指标估计处理效应:替代得分与替代指数

Estimating the long-term effects of treatments is of interest in many fields. A common challenge in estimating such treatment effects is that long-term outcomes are unobserved in the time frame needed to make policy decisions. One approach to overcome this missing data problem is to analyze treatments effects on an intermediate outcome, often called a statistical surrogate, if it satisfies the condition that treatment and outcome are independent conditional on the…

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SPORTSCausal: Spill-Over Time Series Causal Inference

SPORTSCausal:存在溢出效应的时间序列因果推断

Randomized controlled trials (RCTs) have long been the gold standard for causal inference across various fields, including business analysis, economic studies, sociology, clinical research, and network learning. The primary advantage of RCTs over observational studies lies in their ability to significantly reduce noise from individual variance. However, RCTs depend on strong assumptions, such as group independence, time independence, and group randomness, which are not…

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Gradient Wild Bootstrap for Instrumental Variable Quantile Regressions with Weak and Few Clusters

少数大聚类与弱识别下工具变量分位数回归的梯度野生自助法

We study the gradient wild bootstrap-based inference for instrumental variable quantile regressions in the framework of a small number of large clusters in which the number of clusters is viewed as fixed, and the number of observations for each cluster diverges to infinity. For the Wald inference, we show that our wild bootstrap Wald test, with or without studentization using the cluster-robust covariance estimator (CRVE), controls size asymptotically up to a small error as…

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Valid Inference After Causal Discovery

因果发现之后的有效推断

Causal discovery and causal effect estimation are two fundamental tasks in causal inference. While many methods have been developed for each task individually, statistical challenges arise when applying these methods jointly: estimating causal effects after running causal discovery algorithms on the same data leads to "double dipping," invalidating the coverage guarantees of classical confidence intervals. To this end, we develop tools for valid post-causal-discovery…

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Treatment bootstrapping: A new approach to quantify uncertainty of average treatment effect estimates

处理组自助法:量化匹配处理效应估计的不确定性

This paper proposes a new non-parametric bootstrap method to quantify the uncertainty of average treatment effect estimate for the treated from matching estimators. More specifically, it seeks to quantify the uncertainty associated with the average treatment effect estimate for the treated by bootstrapping the treatment group only and finding the counterpart control group by pair matching on estimated propensity score without replacement. We demonstrate the validity of this…

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Non-Plug-In Estimators Could Outperform Plug-In Estimators: a Cautionary Note and a Diagnosis

非代入估计量可能优于代入估计量:警示与诊断

Objectives: Highly flexible nonparametric estimators have gained popularity in causal inference and epidemiology. Popular examples of such estimators include targeted maximum likelihood estimators (TMLE) and double machine learning (DML). TMLE is often argued or suggested to be better than DML estimators and several other estimators in small to moderate samples -- even if they share the same large-sample properties -- because TMLE is a plug-in estimator and respects the…

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