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SNPL：面向安全多目标改进的同步策略学习与评估AI 解读

To design effective digital interventions, experimenters face the challenge of learning decision policies that balance multiple objectives using offline data. Often, they aim to develop policies that maximize goal outcomes, while ensuring there are no undesirable changes in guardrail outcomes. To provide credible recommendations, experimenters must not only identify policies that satisfy the desired changes in goal and guardrail outcomes, but also offer probabilistic…

基于有限医学检测与用药数据的数据协作因果推断AI 解读

Observational studies enable causal inferences when randomized controlled trials (RCTs) are not feasible. However, integrating sensitive medical data across multiple institutions introduces significant privacy challenges. The data collaboration quasi-experiment (DC-QE) framework addresses these concerns by sharing "intermediate representations" -- dimensionality-reduced data derived from raw data -- instead of the raw data. While the DC-QE can estimate treatment effects, its…

因果目标量选择的统一框架AI 解读

Estimating the causal effect of a treatment or health policy with observational data can be challenging due to an imbalance of and a lack of overlap between treated and control covariate distributions. In the presence of limited overlap, researchers choose between 1) methods (e.g., inverse probability weighting) that imply traditional estimands but whose estimators are at risk of considerable bias and variance; and 2) methods (e.g., overlap weighting) which imply a different…

用于纵向因果推断的反馈增强非齐次隐马尔可夫模型AI 解读

Hidden Markov models are widely used for modeling sequential data but typically have limited applicability in observational causal inference due to their strong conditional independence assumptions. I introduce feedback-augmented non-homogeneous hidden Markov model (FAN-HMM), which incorporate time-varying covariates and feedback mechanisms from past observations to latent states and future responses. Integrating these models with the structural causal model framework allows…

利用结局信息加权的稳健平均处理效应估计AI 解读

Reliable causal effect estimation from observational data requires adjustment for confounding and sufficient overlap in covariate distributions between treatment groups. However, in high-dimensional settings, lack of overlap often inflates the variance and weakens the robustness of inverse propensity score weighting (IPW) based estimators. Although many approaches that rely on covariate adjustment have been proposed to mitigate these issues, we instead shift the focus to the…

利用协变量平衡程序进行因果效应的一般贝叶斯推断AI 解读

In observational studies, the propensity score plays a central role in estimating causal effects of interest. The inverse probability weighting (IPW) estimator is commonly used for this purpose. However, if the propensity score model is misspecified, the IPW estimator may produce biased estimates of causal effects. Previous studies have proposed some robust propensity score estimation procedures. However, these methods require considering parameters that dominate the…

删失与隐藏混杂下高维随机试验和真实世界数据的整合分析AI 解读

In this study, we focus on estimating the heterogeneous treatment effect (HTE) for survival outcome. The outcome is subject to censoring and the number of covariates is high-dimensional. We utilize data from both the randomized controlled trial (RCT), considered as the gold standard, and real-world data (RWD), possibly affected by hidden confounding factors. To achieve a more efficient HTE estimate, such integrative analysis requires great insight into the data generation…

存在不依从的随机实验中的稳健识别AI 解读

Instrument variable (IV) methods are widely used in empirical research to identify causal effects of a policy. In the local average treatment effect (LATE) framework, the IV estimand identifies the LATE under three main assumptions: random assignment, exclusion restriction, and monotonicity. However, these assumptions are often questionable in many applications, leading some researchers to doubt the causal interpretation of the IV estimand. This paper considers a robust…

逻辑斯蒂—正态混合模型下高维亚组分析的收缩似然比检验AI 解读

In subgroup analysis, testing the existence of a subgroup with a differential treatment effect serves as protection against spurious subgroup discovery. Despite its importance, this hypothesis testing possesses a complicated nature: parameter characterizing subgroup classification is not identified under the null hypothesis of no subgroup. Due to this irregularity, the existing methods have the following two limitations. First, the asymptotic null distribution of test…

不同因果发现情境下重抽样技术交互作用的大规模模拟研究AI 解读

Despite the accelerating presence of exploratory causal analysis in modern science and medicine, the available non-experimental methods for validating causal models are not well characterized. One of the most popular methods is to evaluate the stability of model features after resampling the data, similar to resampling methods for estimating confidence intervals in statistics. Many aspects of this approach have received little to no attention, however, such as whether the…

部分识别计量模型的线性规划方法AI 解读

Sharp bounds on partially identified parameters are often given by the values of linear programs (LPs). This paper introduces a novel estimator of the LP value. Unlike existing procedures, our estimator is root-n-consistent, pointwise in the probability measure, whenever the population LP is feasible and finite. Our estimator is valid under point-identification, over-identifying constraints, and solution multiplicity. Turning to uniformity properties, we prove that the LP…

使用实验数据验证观察研究的理论困难AI 解读

Observational data is often readily available in large quantities, but can lead to biased causal effect estimates due to the presence of unobserved confounding. Recent works attempt to remove this bias by supplementing observational data with experimental data, which, when available, is typically on a smaller scale due to the time and cost involved in running a randomised controlled trial. In this work, we prove a theorem that places fundamental limits on this ``best of both…

一般处理分配概率下实验设计的分布差异问题AI 解读

We investigate experimental design for randomized controlled trials (RCTs) with both equal and unequal treatment-control assignment probabilities. Our work makes progress on the connection between the distributional discrepancy minimization (DDM) problem introduced by Harshaw et al. (2024) and the design of RCTs. We make two main contributions: First, we prove that approximating the optimal solution of the DDM problem within a certain constant error is NP-hard. Second, we…

半参数有效半监督学习的统一框架AI 解读

We consider statistical inference under a semi-supervised setting where we have access to both a labeled dataset consisting of pairs $\{X_i, Y_i \}_{i=1}^n$ and an unlabeled dataset $\{ X_i \}_{i=n+1}^{n+N}$. We ask the question: under what circumstances, and by how much, can incorporating the unlabeled dataset improve upon inference using the labeled data? To answer this question, we investigate semi-supervised learning through the lens of semiparametric efficiency theory.…

基于变分因果推断的反事实生成建模AI 解读

Estimating an individual's counterfactual outcomes under interventions is a challenging task for traditional causal inference and supervised learning approaches when the outcome is high-dimensional (e.g. gene expressions, facial images) and covariates are relatively limited. In this case, to predict one's outcomes under counterfactual treatments, it is crucial to leverage individual information contained in the observed outcome in addition to the covariates. Prior works…

共享单车缺车如何影响用户出行方式转换：来自南京的证据AI 解读

Dockless bike-sharing (DBS) users often encounter difficulties in finding available bikes at their preferred times and locations. This study examines the determinants of the users' mode shifts in the context of bike absence, using survey data from Nanjing, China. An integrated choice and latent variable based on multinomial logit was employed to investigate the impact of socio-demographic, trip characteristics, and psychological factors on travel mode choices. Mode choice…

二元 V 形结构中因果效应估计量的协方差AI 解读

Previously [Journal of Causal Inference, 10, 90-105 (2022)], we computed the variance of two estimators of causal effects for a v-structure of binary variables. Here we show that a linear combination of these estimators has lower variance than either. Furthermore, we show that this holds also when the treatment variable is block randomised with a predefined number receiving treatment, with analogous results to when it is sampled randomly.

适用于多种删失机制的生存数据灵活控制函数方法AI 解读

This paper addresses the problem of identifying and estimating the causal effect of a treatment in the presence of unmeasured confounding and various types of right-censoring. Examples of these censoring mechanisms are administrative censoring, competing risks and dependent censoring (e.g. loss to follow-up). Different parametric transformations are applied to each event time, resulting in a regression model with a more additive structure and error terms that are…

利用广义随机森林非参数估计条件密度AI 解读

Considering a continuous random variable Y together with a continuous random vector X, I propose a nonparametric estimator f^(.|x) for the conditional density of Y given X=x. This estimator takes the form of an exponential series whose coefficients Tx = (Tx1,...,TxJ) are the solution of a system of nonlinear equations that depends on an estimator of the conditional expectation E[p(Y)|X=x], where p is a J-dimensional vector of basis functions. The distinguishing feature of…

fkbma：以自由节点 B 样条和贝叶斯模型平均识别治疗定制变量的 R 包AI 解读

Precision medicine aims to optimize treatment by identifying patient subgroups most likely to benefit from specific interventions. To support this goal, we introduce fkbma, an R package that implements a Bayesian model averaging approach with free-knot B-splines for identifying tailoring variables. The package employs a reversible jump Markov chain Monte Carlo algorithm to flexibly model treatment effect heterogeneity while accounting for uncertainty in both variable…

随机临床试验协变量调整中基于影响函数方差的稳健 g 计算得分检验AI 解读

G-computation has become a widely used robust method for estimating unconditional (marginal) treatment effects with covariate adjustment in the analysis of randomized clinical trials. Statistical inference in this context typically relies on the Wald test or Wald interval, which can be easily implemented using a consistent variance estimator. However, existing literature suggests that when sample sizes are small or when parameters of interest are near boundary values,…

用于因果效应估计的组合式模型AI 解读

Many real-world systems can be usefully represented as sets of interacting components. Examples include computational systems, such as query processors and compilers, natural systems, such as cells and ecosystems, and social systems, such as families and organizations. However, current approaches to estimating potential outcomes and causal effects typically treat such systems as single units, represent them with a fixed set of variables, and assume a homogeneous…

未测混杂下生存结局平均处理效应的双重稳健工具变量方法AI 解读

Motivated by conflicting conclusions regarding hydrocortisone's treatment effect on ICU patients with vasopressor-dependent septic shock, we developed a novel instrumental variable (IV) estimator to assess the average treatment effect (ATE) in time-to-event data. In real-world data, IV methods are widely used for estimating causal treatment effects in the presence of unmeasured confounding, but existing approaches for time-to-event outcomes are often constrained by strong…

中介与时变剂量反应曲线的序贯核嵌入AI 解读

We propose simple nonparametric estimators for mediated and time-varying dose response curves based on kernel ridge regression. By embedding Pearl's mediation formula and Robins' g-formula with kernels, we allow treatments, mediators, and covariates to be continuous in general spaces, and also allow for nonlinear treatment-confounder feedback. Our key innovation is a reproducing kernel Hilbert space technique called sequential kernel embedding, which we use to construct…