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Optimization-based Sensitivity Analysis for Unmeasured Confounding using Partial Correlations

利用偏相关的未观测混杂优化敏感性分析

Causal inference necessarily relies upon untestable assumptions; hence, it is crucial to assess the robustness of obtained results to violations of identification assumptions. However, such sensitivity analysis is only occasionally undertaken in practice, as many existing methods require analytically tractable solutions and their results are often difficult to interpret. We take a more flexible approach to sensitivity analysis and view it as a constrained stochastic…

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A Cautionary Tale on Integrating Studies with Disparate Outcome Measures for Causal Inference

结局测量不同的研究整合用于因果推断时的警示

Data integration approaches are increasingly used to enhance the efficiency and generalizability of studies. However, a key limitation of these methods is the assumption that outcome measures are identical across datasets -- an assumption that often does not hold in practice. Consider the following opioid use disorder (OUD) studies: the XBOT trial and the POAT study, both evaluating the effect of medications for OUD on withdrawal symptom severity (not the primary outcome of…

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A Computational Theory for Efficient Mini Agent Evaluation with Causal Guarantees

具有因果保证的高效小型智能体评估计算理论

In order to reduce the cost of experimental evaluation for agents, we introduce a computational theory of evaluation for mini agents: build evaluation model to accelerate the evaluation procedures. We prove upper bounds of generalized error and generalized causal effect error of given evaluation models for infinite agents. We also prove efficiency, and consistency to estimated causal effect from deployed agents to evaluation metric by prediction. To learn evaluation models,…

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Welfare Analysis in Dynamic Models

动态模型中的福利分析

This paper introduces metrics for welfare analysis in dynamic models. We develop estimation and inference for these parameters even in the presence of a high-dimensional state space. Examples of welfare metrics include average welfare, average marginal welfare effects, and welfare decompositions into direct and indirect effects similar to Oaxaca (1973) and Blinder (1973). We derive dual and doubly robust representations of welfare metrics that facilitate debiased inference.…

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Targeted Learning Estimation of Sampling Variance for Improved Inference

以目标学习估计抽样方差以改进推断

For robust statistical inference it is crucial to obtain a good estimator of the variance of the proposed estimator of the statistical estimand. A commonly used estimator of the variance for an asymptotically linear estimator is the sample variance of the estimated influence function. This estimator has been shown to be anti-conservative in limited samples or in the presence of near-positivity violations, leading to elevated Type-I error rates and poor coverage. In this…

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Causal discovery on vector-valued variables and consistency-guided aggregation

向量值变量的因果发现与一致性引导的聚合

Causal discovery (CD) aims to discover the causal graph underlying the data generation mechanism of observed variables. In many real-world applications, the observed variables are vector-valued, such as in climate science where variables are defined over a spatial grid and the task is called spatio-temporal causal discovery. We motivate CD in vector-valued variable setting while considering different possibilities for the underlying model, and highlight the pitfalls of…

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Efficient estimation of the target population average treatment effect from multi-source data

利用多来源数据高效估计目标总体平均处理效应

We consider estimation of the target population average treatment effect (TATE) when outcome information is unavailable. Instead, we observe the outcome in multiple source populations and wish to combine the treatment effects therein to make inference on the TATE. In contrast to existing works that assume transportability on the conditional distribution of potential outcomes or conditional treatment-specific means, we work under a weaker form of effect transportability.…

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A mover-stayer model with time-dependent stayer fraction

具有时变停留者比例的迁移者—停留者模型

Mover-stayer models are used in social sciences and economics to model heterogeneous population dynamics in which some individuals never experience the event of interest ("stayers"), while others transition between states over time ("movers"). Conventionally, the mover-stayer status is determined at baseline and time-dependent covariates are only incorporated in the movers' transition probabilities. In this paper, we present a novel dynamic version of the mover-stayer model,…

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Sequential Treatment Effect Estimation with Unmeasured Confounders

存在未测量混杂时的序贯处理效应估计

This paper studies the cumulative causal effects of sequential treatments in the presence of unmeasured confounders. It is a critical issue in sequential decision-making scenarios where treatment decisions and outcomes dynamically evolve over time. Advanced causal methods apply transformer as a backbone to model such time sequences, which shows superiority in capturing long time dependence and periodic patterns via attention mechanism. However, even they control the observed…

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Asymptotically Efficient Data-adaptive Penalized Shrinkage Estimation with Application to Causal Inference

渐近有效的数据自适应惩罚收缩估计及其因果推断应用

A rich literature exists on constructing non-parametric estimators with optimal asymptotic properties. In addition to asymptotic guarantees, it is often of interest to design estimators with desirable finite-sample properties; such as reduced mean-squared error of a large set of parameters. We provide examples drawn from causal inference where this may be the case, such as estimating a large number of group-specific treatment effects. We show how finite-sample properties of…

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Robust Estimation and Inference in Panels with Interactive Fixed Effects

交互固定效应面板中的稳健估计与推断

We consider estimation and inference for a regression coefficient in panels with interactive fixed effects (i.e., with a factor structure). We demonstrate that existing estimators and confidence intervals (CIs) can be heavily biased and size-distorted when some of the factors are weak. We propose estimators with improved rates of convergence and bias-aware CIs that remain valid uniformly, regardless of factor strength. Our approach applies the theory of minimax linear…

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Integrating Large Language Models in Causal Discovery: A Statistical Causal Approach

将大语言模型融入因果发现:统计因果方法

In practical statistical causal discovery (SCD), embedding domain expert knowledge as constraints into the algorithm is important for reasonable causal models reflecting the broad knowledge of domain experts, despite the challenges in the systematic acquisition of background knowledge. To overcome these challenges, this paper proposes a novel method for causal inference, in which SCD and knowledge-based causal inference (KBCI) with a large language model (LLM) are…

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Adjusted Nelson--Aalen estimators by inverse treatment probability weighting with an estimated propensity score

使用估计倾向得分进行逆处理概率加权的调整 Nelson–Aalen 估计

Inverse probability of treatment weighting (IPW) has been well applied in causal inference to estimate population-level estimands from observational studies. For time-to-event outcomes, the failure time distribution can be estimated by estimating the cumulative hazard in the presence of random right censoring. IPW can be performed by weighting the event counting process and at-risk process by the inverse treatment probability, resulting in an adjusted Nelson--Aalen estimator…

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Transformers Handle Endogeneity in In-Context Linear Regression

Transformer 在上下文线性回归中处理内生性

We explore the capability of transformers to address endogeneity in in-context linear regression. Our main finding is that transformers inherently possess a mechanism to handle endogeneity effectively using instrumental variables (IV). First, we demonstrate that the transformer architecture can emulate a gradient-based bi-level optimization procedure that converges to the widely used two-stage least squares $(\textsf{2SLS})$ solution at an exponential rate. Next, we propose…

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Generalized M-Estimation in Censored Regression Model under Endogeneity

内生性下删失回归模型的广义 M 估计

We propose and study M-estimation to estimate the parameters in the censored regression model in the presence of endogeneity, i.e., the Tobit model. In the course of this study, we follow two-stage procedures: the first stage consists of applying control function procedures to address the issue of endogeneity using instrumental variables, and the second stage applies the M-estimation technique to estimate the unknown parameters involved in the model. The large sample…

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Borrowing strength between unaligned binary time-series via Bayesian nonparametric rescaling of Unified Skewed Normal priors

通过统一偏斜正态先验的贝叶斯非参数重缩放共享未对齐二元时间序列信息

We define a Bayesian semi-parametric model to effectively conduct inference with unaligned longitudinal binary data. The proposed strategy is motivated by data from the Human Epilepsy Project (HEP), which collects seizure occurrence data for epilepsy patients, together with relevant covariates. The model is designed to flexibly accommodate the particular challenges that arise with such data. First, epilepsy data require models that can allow for extensive heterogeneity,…

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Doublethink: simultaneous Bayesian-frequentist model-averaged hypothesis testing

双思:贝叶斯与频率派模型平均假设检验的同时实现

Establishing the frequentist properties of Bayesian approaches widens their appeal and offers new understanding. In hypothesis testing, Bayesian model averaging addresses the problem that conclusions are sensitive to variable selection. But Bayesian false discovery rate (FDR) guarantees are sensitive to subjective prior assumptions. Here we show that Bayesian model-averaged hypothesis testing is a closed testing procedure that controls the frequentist familywise error rate…

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Clarifying the Role of the Mantel-Haenszel Risk Difference Estimator in Randomized Clinical Trials

厘清随机临床试验中 Mantel–Haenszel 风险差估计量的作用

The Mantel-Haenszel (MH) risk difference estimator, commonly used in randomized clinical trials for binary outcomes, calculates a weighted average of stratum-specific risk difference estimators. Traditionally, this method requires the stringent assumption that risk differences are homogeneous across strata, also known as the common (constant) risk difference assumption. In our article, we relax this assumption and adopt a modern perspective, viewing the MH risk difference…

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Constrained Design of a Binary Instrument in a Partially Linear Model

部分线性模型中二元工具变量的约束设计

We study the question of how best to assign an encouragement in a randomized encouragement study. In our setting, units arrive with covariates, receive a nudge toward treatment or control, acquire one of those statuses in a way that need not align with the nudge, and finally have a response observed. The nudge can be modeled as a binary instrument if one assumes that it affects the response only via the treatment status. Our goal is to assign the nudge as a function of…

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Policy Relevant Treatment Effects with Multidimensional Unobserved Heterogeneity

多维未观测异质性下的政策相关处理效应

This paper provides a unified framework for bounding policy relevant treatment effects using instrumental variables. In this framework, the treatment selection may depend on multidimensional unobserved heterogeneity. We derive bilinear constraints on the target parameter by extracting information from identifiable estimands. We apply a convex relaxation method to these bilinear constraints and provide conservative yet computationally simple bounds. Our convex-relaxation…

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A Unified Approach to Covariate Adjustment for Survival Endpoints in Randomized Clinical Trials

随机临床试验中生存终点协变量调整的统一方法

Covariate adjustment aims to improve the statistical efficiency of randomized trials by incorporating information from baseline covariates. Popular methods for covariate adjustment include analysis of covariance for continuous endpoints and standardized logistic regression for binary endpoints. For survival endpoints, while some covariate adjustment methods have been developed for specific effect measures, they are not commonly used in practice for various reasons, including…

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Just Ask Them Twice: Choice Probabilities and Identification of Ex ante returns and Willingness-To-Pay

只需询问两次:选择概率、事前收益与支付意愿的识别

One of the exciting developments in the stated preference literature is the use of probabilistic stated preference experiments to estimate semi-parametric population distributions of ex ante returns and willingness-to-pay (WTP) for a choice attribute. This relies on eliciting several choices per individual, and estimating separate demand functions, at the cost of possibly long survey instruments. This paper shows that the distributions of interest can be recovered from at…

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Decomposition of Probabilities of Causation with Two Mediators

含两个中介变量的致因概率分解

Mediation analysis for probabilities of causation (PoC) provides a fundamental framework for evaluating the necessity and sufficiency of treatment in provoking an event through different causal pathways. One of the primary objectives of causal mediation analysis is to decompose the total effect into path-specific components. In this study, we investigate the path-specific probability of necessity and sufficiency (PNS) to decompose the total PNS into path-specific components…

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Low-Rank Regularization of Global Fréchet Regression Models for Distributional Responses

分布响应的全局Fréchet回归低秩正则化

Fréchet regression has emerged as a useful tool for modeling non-Euclidean response variables associated with Euclidean covariates. In this work, we propose a global Fréchet regression estimation method that incorporates low-rank regularization. Focusing on distribution function responses, we demonstrate that leveraging the low-rank structure of the model parameters enhances both the efficiency and accuracy of model fitting. Through theoretical analysis of the large-sample…

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