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Improving precision of cumulative incidence estimates in randomized controlled trials with external controls

利用外部对照提高随机试验累积发生率估计的精度

Augmenting the control arm in clinical trials with external data can improve statistical power for demonstrating treatment effects. In many time-to-event outcome trials, participants are subject to truncation by death. Direct application of methods for competing risks analysis on the joint data may introduce bias, for example, due to covariate shifts between the populations. In this work, we consider transportability of the conditional cause-specific hazard of the event of…

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The Persistent Effects of Peru's Mining MITA: Double Machine Learning Approach

秘鲁矿业米塔制度的持久影响:双重机器学习方法

This study examines the long-term economic impact of the colonial Mita system in Peru, building on Melissa Dell's foundational work on the enduring effects of forced labor institutions. The Mita, imposed by the Spanish colonial authorities from 1573 to 1812, required indigenous communities within a designated boundary to supply labor to mines, primarily near Potosi. Dell's original regression discontinuity design (RDD) analysis, leveraging the Mita boundary to estimate the…

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Beyond utility: incorporating eye-tracking, skin conductance and heart rate data into cognitive and econometric travel behaviour models

超越效用:将眼动、皮肤电导与心率纳入出行行为模型

Choice models for large-scale applications have historically relied on economic theories (e.g. utility maximisation) that establish relationships between the choices of individuals, their characteristics, and the attributes of the alternatives. In a parallel stream, choice models in cognitive psychology have focused on modelling the decision-making process, but typically in controlled scenarios. Recent research developments have attempted to bridge the modelling paradigms,…

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An Empirical Comparison of Weak-IV-Robust Procedures in Just-Identified Models

恰好识别模型中弱工具变量稳健推断程序的实证比较

Instrumental variable (IV) regression is recognized as one of the five core methods for causal inference, as identified by Angrist and Pischke (2008). This paper compares two leading approaches to inference under weak identification for just-identified IV models: the classical Anderson-Rubin (AR) procedure and the recently popular tF method proposed by Lee et al. (2022). Using replication data from the American Economic Review (AER) and Monte Carlo simulation experiments, we…

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Structural restrictions in local causal discovery: identifying direct causes of a target variable

局部因果发现中的结构限制:识别目标变量的直接原因

We consider the problem of learning a set of direct causes of a target variable from an observational joint distribution. Learning directed acyclic graphs (DAGs) that represent the causal structure is a fundamental problem in science. Several results are known when the full DAG is identifiable from the distribution, such as assuming a nonlinear Gaussian data-generating process. Here, we are only interested in identifying the direct causes of one target variable (local causal…

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Efficient Difference-in-Differences and Event Study Estimators

高效的双重差分与事件研究估计量

This paper investigates efficient Difference-in-Differences (DiD) and Event Study (ES) estimation using short panel data sets within the heterogeneous treatment effect framework, free from parametric functional form assumptions and allowing for variation in treatment timing. We provide an equivalent characterization of the DiD potential outcome model using sequential conditional moment restrictions on observables, which shows that the DiD identification assumptions typically…

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Decision Theory for Treatment Choice Problems with Partial Identification

部分识别下处理选择问题的决策理论

We apply classical statistical decision theory to a large class of treatment choice problems with partial identification. We show that, in a general class of problems with Gaussian likelihood, all decision rules are admissible; it is maximin-welfare optimal to ignore all data; and, for severe enough partial identification, there are infinitely many minimax-regret optimal decision rules, all of which sometimes randomize the policy recommendation. We uniquely characterize the…

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Regularized Targeted Maximum Likelihood Estimation in Highly Adaptive Lasso Implied Working Models

高适应Lasso隐含工作模型中的正则化目标最大似然估计

We address the challenge of performing Targeted Maximum Likelihood Estimation (TMLE) after an initial Highly Adaptive Lasso (HAL) fit. Existing approaches that utilize the data-adaptive working model selected by HAL-such as the relaxed HAL update-can be simple and versatile but may become computationally unstable when the HAL basis expansions introduce collinearity. Undersmoothed HAL may fail to solve the efficient influence curve (EIC) at the desired level without…

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Autoregressive Hypergraph

自回归超图模型

Traditional graph representations are insufficient for modelling real-world phenomena involving multi-entity interactions, such as collaborative projects or protein complexes, necessitating the use of hypergraphs. While hypergraphs preserve the intrinsic nature of such complex relationships, existing models often overlook temporal evolution in relational data. To address this, we introduce a first-order autoregressive (i.e. AR(1)) model for dynamic non-uniform hypergraphs.…

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When Can We Use Two-Way Fixed-Effects (TWFE): A Comparison of TWFE and Novel Dynamic Difference-in-Differences Estimators

何时可以使用双向固定效应:与新型动态双重差分估计量的比较

The conventional Two-Way Fixed-Effects (TWFE) estimator has come under scrutiny lately. Recent literature has revealed potential shortcomings of TWFE when the treatment effects are heterogeneous. Scholars have developed new advanced dynamic Difference-in-Differences (DiD) estimators to tackle these potential shortcomings. However, confusion remains in applied research as to when the conventional TWFE is biased and what issues the novel estimators can and cannot address. In…

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FedECA: Federated External Control Arms for Causal Inference with Time-To-Event Data in Distributed Settings

FedECA:分布式生存数据因果推断的联邦外部对照组

External control arms can inform early clinical development of experimental drugs and provide efficacy evidence for regulatory approval. However, accessing sufficient real-world or historical clinical trials data is challenging. Indeed, regulations protecting patients' rights by strictly controlling data processing make pooling data from multiple sources in a central server often difficult. To address these limitations, we develop a method that leverages federated learning…

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Adaptive Experimental Design for Policy Learning

用于政策学习的自适应实验设计

This study investigates the contextual best arm identification (BAI) problem, aiming to design an adaptive experiment to identify the best treatment arm conditioned on contextual information (covariates). We consider a decision-maker who assigns treatment arms to experimental units during an experiment and recommends the estimated best treatment arm based on the contexts at the end of the experiment. The decision-maker uses a policy for recommendations, which is a function…

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Estimating Multiple Weighted Networks with Node-Sparse Differences and Shared Low-Rank Structure

估计具有节点稀疏差异与共享低秩结构的多个加权网络

We study the problem of modeling multiple symmetric, weighted networks defined on a common set of nodes, where networks arise from different groups or conditions. We propose a model in which each network is expressed as the sum of a shared low-rank structure and a node-sparse matrix that captures the differences between conditions. This formulation is motivated by practical scenarios, such as in connectomics, where most nodes share a global connectivity structure while only…

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Sequential Synthetic Difference in Differences

序贯合成双重差分

We propose the Sequential Synthetic Difference-in-Differences (Sequential SDiD) estimator for event studies with staggered treatment adoption, particularly when the parallel trends assumption fails. The method uses an iterative imputation procedure on aggregated data, where estimates for early-adopting cohorts are used to construct counterfactuals for later ones. We prove the estimator is asymptotically equivalent to an infeasible oracle OLS estimator within a linear model…

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Statistical Learning for Heterogeneous Treatment Effects: Pretraining, Prognosis, and Prediction

异质性处理效应的统计学习:预训练、预后与预测

Robust estimation of heterogeneous treatment effects is a fundamental challenge for optimal decision-making in domains ranging from personalized medicine to educational policy. In recent years, predictive machine learning has emerged as a valuable toolbox for causal estimation, enabling more flexible effect estimation. However, accurately estimating conditional average treatment effects (CATE) remains a major challenge, particularly in the presence of many covariates. In…

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Towards Robust Causal Effect Identification Beyond Markov Equivalence

超越马尔可夫等价类的稳健因果效应识别

Causal effect identification typically requires a fully specified causal graph, which can be difficult to obtain in practice. We provide a sufficient criterion for identifying causal effects from a candidate set of Markov equivalence classes with added background knowledge, which represents cases where determining the causal graph up to a single Markov equivalence class is challenging. Such cases can happen, for example, when the untestable assumptions (e.g. faithfulness)…

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KANITE: Kolmogorov-Arnold Networks for ITE estimation

KANITE:用于个体处理效应估计的 Kolmogorov–Arnold 网络

We introduce KANITE, a framework leveraging Kolmogorov-Arnold Networks (KANs) for Individual Treatment Effect (ITE) estimation under multiple treatments setting in causal inference. By utilizing KAN's unique abilities to learn univariate activation functions as opposed to learning linear weights by Multi-Layer Perceptrons (MLPs), we improve the estimates of ITEs. The KANITE framework comprises two key architectures: 1.Integral Probability Metric (IPM) architecture: This…

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Fast computation of exact confidence intervals for randomized experiments with binary outcomes

二元结果随机实验精确置信区间的快速计算

Given a randomized experiment with binary outcomes, exact confidence intervals for the average causal effect of the treatment can be computed through a series of permutation tests. This approach requires minimal assumptions and is valid for all sample sizes, as it does not rely on large-sample approximations such as those implied by the central limit theorem. We show that these confidence intervals can be found in $O(n \log n)$ permutation tests in the case of balanced…

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Causal inference amid missingness-specific independencies and mechanism shifts

缺失特定独立性与机制变化下的因果推断

The recovery of causal effects in structural models with missing data often relies on $m$-graphs, which assume that missingness mechanisms do not directly influence substantive variables. Yet, in many real-world settings, missing data can alter decision-making processes, as the absence of key information may affect downstream actions and states. To overcome this limitation, we introduce $lm$-SCMs and $lm$-graphs, which extend $m$-graphs by integrating a label set that…

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Linear-Time Primitives for Algorithm Development in Graphical Causal Inference

图形因果推断算法开发的线性时间基础操作

We introduce CIfly, a framework for efficient algorithmic primitives in graphical causal inference that isolates reachability as a reusable core operation. It builds on the insight that many causal reasoning tasks can be reduced to reachability in purpose-built state-space graphs that can be constructed on the fly during traversal. We formalize a rule table schema for specifying such algorithms and prove they run in linear time. We establish CIfly as a more efficient…

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Quantile Treatment Effects in High Dimensional Panel Data

高维面板数据中的分位数处理效应

We introduce novel estimators for quantile causal effects with high dimensional panel data (large $N$ and $T$), where only one or a few units are affected by the intervention or policy. Our method extends the generalized synthetic control method \citep{xu_2017} from average treatment effects on the treated to quantile treatment effects on the treated, allowing the underlying factor structure to change across the quantile of the interested outcome distribution. Our method…

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On the relationship between prediction intervals, tests of sharp nulls and inference on realized treatment effects in settings with few treated units

少量处理单位下预测区间、尖锐原假设检验与已实现处理效应推断的关系

We study how inference methods for settings with few treated units that rely on treatment effect homogeneity extend to alternative inferential targets when treatment effects are heterogeneous -- namely, tests of sharp null hypotheses, inference on realized treatment effects, and prediction intervals. We show that inference methods for these alternative targets are deeply interconnected: they are either equivalent or become equivalent under additional assumptions. Our results…

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Identifiability by common backdoor in summary causal graphs of time series

时间序列汇总因果图中基于共同后门集合的可识别性

The identifiability problem for interventions aims at assessing whether the total effect of some given interventions can be written with a do-free formula, and thus be computed from observational data only. We study this problem, considering multiple interventions and multiple effects, in the context of time series when only abstractions of the true causal graph in the form of summary causal graphs are available. We focus in this study on identifiability by a common backdoor…

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Complete Characterization for Adjustment in Summary Causal Graphs of Time Series

时间序列汇总因果图中调整方法的完整刻画

The identifiability problem for interventions aims at assessing whether the total causal effect can be written with a do-free formula, and thus be estimated from observational data only. We study this problem, considering multiple interventions, in the context of time series when only an abstraction of the true causal graph, in the form of a summary causal graph, is available. We propose in particular both necessary and sufficient conditions for the adjustment criterion,…

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