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The Effect of Alcohol intake on Brain White Matter Microstructural Integrity: A New Causal Inference Framework for Incomplete Phenomic Data

饮酒对脑白质微结构完整性的影响:不完整表型数据的因果推断框架

Although substance use, such as alcohol intake, is known to be associated with cognitive decline during aging, its direct influence on the central nervous system remains incompletely understood. In this study, we investigate the influence of alcohol intake frequency on reduction of brain white matter microstructural integrity in the fornix, a brain region considered a promising marker of age-related microstructural degeneration, using a large UK Biobank (UKB) cohort with…

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Adaptive Proximal Causal Inference with Some Invalid Proxies

含部分无效代理变量的自适应近端因果推断

Proximal causal inference (PCI) is a recently proposed framework to identify and estimate the causal effect of an exposure on an outcome in the presence of hidden confounders, using observed proxies. Specifically, PCI relies on two types of proxies: a treatment-inducing confounding proxy, related to the outcome only through its association with unmeasured confounders (given treatment and covariates), and an outcome-inducing confounding proxy, related to the treatment only…

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Inference with weights: Residualization produces short, valid intervals for varying estimands and varying resampling processes

加权推断:不同估计目标与重抽样机制下的残差化区间

Weighting procedures are used in observational causal inference to adjust for covariate imbalance within the sample. Common practice for inference is to estimate robust standard errors from a weighted regression of outcome on treatment. However, it is well known that weighting can inflate variance estimates, sometimes significantly, leading to standard errors and confidence intervals that are overly conservative. We instead examine and recommend the use of robust standard…

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Comparing Causal Inference Methods for Point Exposures with Missing Confounders: A Simulation Study

混杂变量缺失时点暴露因果推断方法的模拟比较

Causal inference methods based on electronic health record (EHR) databases must simultaneously handle confounding and missing data. Vast scholarship exists aimed at addressing these two issues separately, but surprisingly few papers attempt to address them simultaneously. In practice, when faced with simultaneous missing data and confounding, analysts may proceed by first imputing missing data and subsequently using outcome regression or inverse-probability weighting (IPW)…

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Testing Sign Congruence Between Two Parameters

两个参数的符号一致性检验

We test the null hypothesis that two parameters $(μ_1,μ_2)$ have the same sign, assuming that (asymptotically) normal estimators $(\hatμ_1,\hatμ_2)$ are available. Examples of this problem include the analysis of heterogeneous treatment effects, causal interpretation of reduced-form estimands, meta-studies, and mediation analysis. A number of tests were recently proposed. We recommend a test that is simple and rejects more often than many of these recent proposals. Like all…

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Production Function Estimation without Invertibility: Imperfectly Competitive Environments and Demand Shocks

无需可逆性的生产函数估计:不完全竞争环境与需求冲击

We advance the proxy variable approach to production function estimation. We show that the invertibility assumption at its heart is testable. We characterize what goes wrong if invertibility fails and what can still be done. We show that rethinking how the estimation procedure is implemented either eliminates or mitigates the bias that arises if invertibility fails. In particular, a simple change to the first step of the estimation procedure provides a first-order bias…

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Flexible estimation of skill formation models

技能形成模型的灵活估计

This paper examines estimation of skill formation models, a critical component in understanding human capital development and its effects on individual outcomes. Existing estimators are either based on moment conditions and only applicable in specific settings or rely on distributional approximations that often do not align with the model. Our method employs an iterative likelihood-based procedure, which flexibly estimates latent variable distributions and recursively…

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Batched Adaptive Network Formation

分批自适应网络形成

Networks are central to many economic and organizational applications, including workplace team formation, social platform recommendations, and classroom friendship development. In these settings, networks are modeled as graphs, with agents as nodes, agent pairs as edges, and edge weights capturing pairwise production or interaction outcomes. This paper develops an adaptive, or \textit{online}, policy that learns to form increasingly effective networks as data accumulates…

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Estimation of conditional average treatment effects on distributed confidential data

分布式保密数据上的条件平均处理效应估计

The estimation of conditional average treatment effects (CATEs) is an important topic in many scientific fields. CATEs can be estimated with high accuracy if data distributed across multiple parties are centralized. However, it is difficult to aggregate such data owing to confidentiality or privacy concerns. To address this issue, we propose data collaboration double machine learning, a method for estimating CATE models using privacy-preserving fusion data constructed from…

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A Liberating Framework from Truncation and Censoring, with Application to Learning Treatment Effects

摆脱截断与删失限制的学习框架及其处理效应应用

Time-to-event outcomes are often subject to left truncation and right censoring. While many survival analysis methods have been developed to handle truncation and censoring, majority of the past works require strong independence assumptions. We relax these stringent assumptions through leveraging covariate information together with orthogonal learning, and develop a liberating framework from left truncation and right censoring so that desirable properties like double…

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Good Controls Gone Bad: Difference-in-Differences with Covariates

好控制变量为何失效:含协变量的双重差分

This paper introduces the two-way common causal covariates (CCC) assumption, which is necessary to get an unbiased estimate of the ATT when using time-varying covariates in existing Difference-in-Differences methods. The two-way CCC assumption implies that the effect of the covariates remain the same between groups and across time periods. This assumption has been implied in previous literature, but has not been explicitly addressed. Through theoretical proofs and a Monte…

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Partitioned Wild Bootstrap for Panel Data Quantile Regression

面板数据分位数回归的分区野生自助法

Practical inference procedures for quantile regression models of panel data have been a pervasive concern in empirical work, and can be especially challenging when the panel is observed over many time periods and temporal dependence needs to be taken into account. In this paper, we propose a new bootstrap method that applies random weighting to a partition of the data -- partition-invariant weights are used in the bootstrap data generating process -- to conduct statistical…

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Identifying Neural Connectivity using Bernoulli Autoregressive Partially Linear Additive Models

用伯努利自回归部分线性可加模型识别神经连接

Characterising the interactions between spiking neurons is central to our understanding of cognitive processes such as memory, perception and decision making. In this work, we consider the problem of inferring connectivity in the brain network from non-stationary high-dimensional spike train data. Under a binned spike count representation of these data, we propose a Bernoulli autoregressive partially linear additive (BAPLA) model to identify the effective connectivity of a…

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Trek-Based Parameter Identification for Linear Causal Models With Arbitrarily Structured Latent Variables

任意结构潜变量下线性因果模型的 Trek 路径参数识别

We develop a criterion to certify whether causal effects are identifiable in linear structural equation models with latent variables. Linear structural equation models correspond to directed graphs whose nodes represent the random variables of interest and whose edges are weighted with linear coefficients that correspond to direct causal effects. In contrast to previous identification methods, we do not restrict ourselves to settings where the latent variables constitute…

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Decoding Consumer Preferences Using Attention-Based Language Models

利用注意力语言模型解读消费者偏好

This paper proposes a new demand estimation method using attention-based language models. An encoder-only language model is trained in a two-stage process to analyze the natural language descriptions of used cars from a large US-based online auction marketplace. The approach enables semi-nonparametrically estimation for the demand primitives of a structural model representing the private valuations and market size for each vehicle listing. In the first stage, the language…

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Identification and Estimation of Causal Effects in High-Frequency Event Studies

高频事件研究中因果效应的识别与估计

We provide precise conditions for nonparametric identification of causal effects by high-frequency event study regressions, which have been used widely in the recent macroeconomics, financial economics and political economy literatures. The high-frequency event study method regresses changes in an outcome variable on a measure of unexpected changes in a policy variable in a narrow time window around an event or a policy announcement (e.g., a 30-minute window around an FOMC…

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Nonparametric "rich covariates" without saturation

无需饱和设定的非参数“丰富协变量”方法

We consider two nonparametric approaches to ensure that linear instrumental variables estimators satisfy the rich-covariates condition emphasized by Blandhol et al. (2025), even when the instrument is not unconditionally randomly assigned and the model is not saturated. Both approaches start with a nonparametric estimate of the expectation of the instrument conditional on the covariates, and ensure that the rich-covariates condition is satisfied either by using as the…

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Doubly robust estimation of optimal treatment regimes for survival data using an instrumental variable

利用工具变量双重稳健估计生存数据的最优治疗规则

In survival contexts, substantial literature exists on estimating optimal treatment regimes, where treatments are assigned based on personal characteristics to maximize the survival probability. These methods assume that a set of covariates is sufficient to deconfound the treatment-outcome relationship. However, this assumption can be limited in observational studies or randomized trials in which non-adherence occurs. Therefore, we propose a novel approach to estimating…

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Dyadic data with ordered outcome variables

具有有序结果变量的成对数据模型

We consider ordered logit models for directed network data that allow for flexible sender and receiver fixed effects that can vary arbitrarily across outcome categories. This structure poses a significant incidental parameter problem, particularly challenging under network sparsity or when some outcome categories are rare. We develop the first estimation method for this setting by extending tetrad-differencing conditional maximum likelihood (CML) techniques from binary…

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Bayesian causal discovery: Posterior concentration and optimal detection

贝叶斯因果发现:后验集中与最优检测

We consider the problem of Bayesian causal discovery for the standard model of linear structural equations with equivariant Gaussian noise. A uniform prior is placed on the space of directed acyclic graphs (DAGs) over a fixed set of variables and, given the graph, independent Gaussian priors are placed on the associated linear coefficients of pairwise interactions. We show that the rate at which the posterior on model space concentrates on the true underlying DAG depends…

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Identifying Conditional Causal Effects in MPDAGs

最大定向部分有向无环图中的条件因果效应识别

We consider identifying a conditional causal effect when a graph is known up to a maximally oriented partially directed acyclic graph (MPDAG). An MPDAG represents an equivalence class of graphs that is restricted by background knowledge and where all variables in the causal model are observed. We provide three results that address identification in this setting: an identification formula when the conditioning set is unaffected by treatment, a generalization of the well-known…

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Bayesian implementation of Targeted Maximum Likelihood Estimation for uncertainty quantification in causal effect estimation

用于因果效应不确定性量化的贝叶斯目标极大似然估计

Robust decision making involves making decisions in the presence of uncertainty and is often used in critical domains such as healthcare, supply chains, and finance. Causality plays a crucial role in decision-making as it predicts the change in an outcome (usually a key performance indicator) due to a treatment (also called an intervention). To facilitate robust decision making using causality, this paper proposes three Bayesian approaches of the popular Targeted Maximum…

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Detecting and Understanding the Difference between Natural Mediation Effects and Their Randomized Interventional Analogues

自然中介效应与随机干预类比量差异的检测与理解

In causal mediation analysis, the natural direct and indirect effects (natural effects) are nonparametrically unidentifiable in the presence of treatment-induced confounding, which motivated the development of randomized interventional analogues (RIAs) of the natural effects. Being easier to identify, the RIAs are becoming widely used in practice. However, applied researchers often interpret RIA estimates as if they were the natural effects, even though the RIAs can be poor…

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Causal Mediation Analysis for Zero-inflated Mixture Mediators

零膨胀混合中介变量的因果中介分析

Causal mediation analysis is an important statistical tool to quantify effects transmitted by intermediate variables from a cause to an outcome. There is a gap in mediation analysis methods to handle mixture mediator data that are zero-inflated with multi-modality and atypical behaviors. We propose an innovative way to model zero-inflated mixture mediators from the perspective of finite mixture distributions to flexibly capture such mediator data. Multiple data types are…

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