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基于汇总数据消除赢家诅咒的稳健孟德尔随机化AI 解读

In the past decade, the increased availability of genome-wide association studies summary data has popularized Mendelian Randomization (MR) for conducting causal inference. MR analyses, incorporating genetic variants as instrumental variables, are known for their robustness against reverse causation bias and unmeasured confounders. Nevertheless, classical MR analyses utilizing summary data may still produce biased causal effect estimates due to the winner's curse and…

用于平均处理效应估计的因子辅助双重深度学习AI 解读

We investigate the problem of estimating the average treatment effect (ATE) under a very general setup where the covariates can be high-dimensional, highly correlated, and can have sparse nonlinear effects on the propensity and outcome models. We present the use of a Double Deep Learning strategy for estimation, which involves combining recently developed factor-augmented deep learning-based estimators, FAST-NN, for both the response functions and propensity scores to…

统计学的挑战：因果关系与因果推断的十二项挑战AI 解读

Causality and causal inference have emerged as core research areas at the interface of modern statistics and domains including biomedical sciences, social sciences, computer science, and beyond. The field's inherently interdisciplinary nature -- particularly the central role of incorporating domain knowledge -- creates a rich and varied set of statistical challenges. Much progress has been made, especially in the last three decades, but there remain many open questions. Our…

不完全区组设计的设计本位因果推断AI 解读

Researchers often turn to block randomization to increase the precision of their inference or due to practical considerations, such as in multisite trials. However, if the number of treatments under consideration is large it might not be feasible or practical to assign all treatments within each block. We develop novel inference results under the finite-population design-based framework for natural alternatives to the complete block design that do not require reducing the…

用随机矩阵理论重新考察多工具变量问题AI 解读

Instrumental variables estimation with many instruments is biased. Traditional bias-adjustments are closely connected to the Silverstein equation. Based on the theory of random matrices, we show that Ridge estimation of the first-stage parameters reduces the implicit price of bias-adjustments. This leads to a trade-off, allowing for less costly estimation of the causal effect, which comes along with improved asymptotic properties. Our theoretical results nest existing ones…

随机实验中实现无偏机器学习协变量调整的条件交叉拟合AI 解读

Randomized experiments are the gold standard for estimating the average treatment effect (ATE). While covariate adjustment can reduce the asymptotic variances of the unbiased Horvitz-Thompson estimators for the ATE, it suffers from finite-sample biases due to data reuse in both prediction and estimation. Traditional sample-splitting and cross-fitting methods can address the problem of data reuse and obtain unbiased estimators. However, they require that the data are…

元分析中研究内与跨研究的亚组比较AI 解读

Subgroup-specific meta-analysis synthesizes treatment effects for patient subgroups across randomized trials. Methods include joint or separate modeling of subgroup effects and treatment-by-subgroup interactions, but inconsistencies arise when subgroup prevalence differs between studies (e.g., proportion of non-smokers). A key distinction is between study-generated evidence within trials and synthesis-generated evidence obtained by contrasting results across trials. This…

存在小群组时的 K-means 面板数据聚类AI 解读

We consider panel data models with group structure. We study the asymptotic behavior of least-squares estimators and information criterion for the number of groups, allowing for the presence of small groups that have an asymptotically negligible relative size. Our contributions are threefold. First, we derive sufficient conditions under which the least-squares estimators are consistent and asymptotically normal. One of the conditions implies that a longer sample period is…

不平等研究中不存在的结果：一种因果方法AI 解读

Scholars of social stratification often study exposures that shape life outcomes. But some outcomes (such as wage) only exist for some people (such as those who are employed). We show how a common practice -- dropping cases with non-existent outcomes -- can obscure causal effects when a treatment affects both outcome existence and outcome values. The effects of both beneficial and harmful treatments can be underestimated. Drawing on existing approaches for principal…

评估临床治疗规则效用的非参数界限AI 解读

Evaluating the value of new clinical treatment rules based on patient characteristics is important but often complicated by hidden confounding factors in observational studies. Standard methods for estimating the average patient outcome if a new rule were universally adopted typically rely on strong, untestable assumptions about these hidden factors. This paper tackles this challenge by developing nonparametric bounds - a range of plausible values - for the expected outcome…

联合分位数收缩：面向非交叉贝叶斯分位数模型的状态空间方法AI 解读

Crossing of fitted conditional quantiles is a prevalent problem for quantile regression models. We propose a new Bayesian modelling framework that penalises multiple quantile regression functions toward the desired non-crossing space. We achieve this by estimating multiple quantiles jointly with a prior on variation across quantiles, a fused shrinkage prior with quantile adaptivity. The posterior is derived from a decision-theoretic general Bayes perspective, whose form…

冠状动脉旁路移植术后再住院的性别差异：MIMIC-IV 数据的稀疏函数因果中介分析AI 解读

Hospital readmissions following coronary artery bypass grafting (CABG) not only impose a substantial cost burden on healthcare systems but also serve as a potential indicator of the quality of medical care. Previous studies of gender effects on complications after CABG surgery have consistently revealed that women tend to suffer worse outcomes. To better understand the causal pathway from gender to the number of rehospitalisations, we study the postoperative central venous…

内生连续处理因果效应的部分识别AI 解读

No unmeasured confounding is a common assumption when reasoning about counterfactual outcomes, but such an assumption may not be plausible in observational studies. Sensitivity analysis is often employed to assess the robustness of causal conclusions to unmeasured confounding, but existing methods are predominantly designed for binary treatments. In this paper, we provide natural extensions of two extensively used sensitivity frameworks -- the Rosenbaum and Marginal…

因果效应与反事实的界限估计AI 解读

Causal inference often hinges on strong assumptions - such as no unmeasured confounding or perfect compliance - that are rarely satisfied in practice. Partial identification offers a principled alternative: instead of relying on unverifiable assumptions to estimate causal effects precisely, it derives bounds that reflect the uncertainty inherent in the data. Despite its theoretical appeal, partial identification remains underutilized in applied work, in part due to the…

去偏且具有半参数效率的变化中变化估计量AI 解读

We present a novel extension of the influential changes-in-changes (CiC) framework of Athey and Imbens (2006) for estimating the average treatment effect on the treated (ATT) and distributional causal effects in panel data with unmeasured confounding. While CiC relaxes the parallel trends assumption in difference-in-differences (DiD), existing methods typically assume a scalar unobserved confounder and monotonic outcome relationships, and lack inference tools that…

基于多方向正则化的并行网络重构AI 解读

Reconstructing large-scale latent networks from observed dynamics is crucial for understanding complex systems. However, the existing methods based on compressive sensing are often rendered infeasible in practice by prohibitive computational and memory costs. To address this challenge, we introduce a new distributed computing framework for efficient large-scale network reconstruction with parallel computing, namely PALMS (Parallel Adaptive Lasso with Multi-directional…

合理量化不确定性：经验贝叶斯歧视检测中的置信区间AI 解读

We revisit empirical Bayes discrimination detection, focusing on uncertainty arising from both partial identification and sampling variability. While prior work has mostly focused on partial identification, we find that some empirical findings are not robust to sampling uncertainty. To better connect statistical evidence to the magnitude of real-world discriminatory behavior, we propose a counterfactual odds-ratio estimand with a attractive properties and interpretation. Our…

二元分布回归：理论、估计及代际流动应用AI 解读

We employ distribution regression (DR) to estimate the joint distribution of two outcome variables conditional on chosen covariates. While Bivariate Distribution Regression (BDR) is useful in a variety of settings, it is particularly valuable when some dependence between the outcomes persists after accounting for the impact of the covariates. Our analysis relies on a result from Chernozhukov et al. (2018) which shows that any conditional joint distribution has a local…

用于因果推断的贝叶斯双重机器学习AI 解读

This paper proposes a simple, novel, and fully-Bayesian approach for causal inference in partially linear models with high-dimensional control variables. Off-the-shelf machine learning methods can introduce biases in the causal parameter known as regularization-induced confounding. To address this, we propose a Bayesian Double Machine Learning (BDML) method, which modifies a standard Bayesian multivariate regression model and recovers the causal effect of interest from the…

多变量孟德尔随机化的一种更稳健方法AI 解读

Multivariable Mendelian randomization (MVMR) uses genetic variants as instrumental variables to infer the direct effects of multiple exposures on an outcome. However, unlike univariable Mendelian randomization, MVMR often faces greater challenges with many weak instruments, which can lead to bias not necessarily toward zero and inflation of type I errors. In this work, we introduce a new asymptotic regime that allows exposures to have varying degrees of instrument strength,…

工具变量回归中弱工具稳健推断的统计学指南及 Python 示例AI 解读

We provide an overview of results relating to estimation and weak-instrument-robust inference in instrumental variables regression. Methods are implemented in the ivmodels software package for Python, which we use to illustrate results.

序贯自适应实验的有效统计估计及其对自适应设计的启示AI 解读

Adaptive experimental designs have gained popularity in clinical trials and online experiments. Unlike traditional, fixed experimental designs, adaptive designs can dynamically adjust treatment randomization probabilities and other design features in response to data accumulated sequentially during the experiment. These adaptations are useful to achieve diverse objectives, including reducing uncertainty in the estimation of causal estimands or increasing participants'…

PanelMatch：时间序列截面数据因果推断的匹配方法AI 解读

Analyzing time-series cross-sectional (also known as longitudinal or panel) data is an important process across a number of fields, including the social sciences, economics, finance, and medicine. PanelMatch is an R package that implements a set of tools enabling researchers to apply matching methods for causal inference with time-series cross-sectional data. Relative to other commonly used methods for longitudinal analyses, like regression with fixed effects, the…

差分隐私下的协变量平衡因果推断AI 解读

Differential privacy is the leading mathematical framework for privacy protection, providing a probabilistic guarantee that safeguards individuals' private information when publishing statistics from a dataset. This guarantee is achieved by applying a randomized algorithm to the original data, which introduces unique challenges in data analysis by distorting inherent patterns. In particular, causal inference using observational data in privacy-sensitive contexts is…