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A longitudinal Bayesian framework for estimating causal dose-response relationships

估计纵向因果剂量反应关系的贝叶斯框架

Existing causal methods for time-varying exposure and time-varying confounding focus on estimating the average causal effect of a time-varying binary treatment on an end-of-study outcome, offering limited tools for characterizing marginal causal dose-response relationships under continuous exposures. We propose a scalable, nonparametric Bayesian framework for estimating marginal longitudinal causal dose-response functions with repeated outcome measurements. Our approach…

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Difference-in-Differences Estimators When No Unit Remains Untreated

We study difference-in-differences designs in which all units are initially untreated and later receive heterogeneous, strictly positive treatment doses. When quasi-untreated units receive doses close to zero, a difference-in-difference estimand using those units as the control group identifies a weighted average treatment effect per unit of treatment, under a parallel-trends assumption. We develop a nonparametric estimator and bias-corrected confidence intervals for this…

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Pseudo-Panel Event Studies: Econometric Foundations for Credible Applications

伪面板事件研究:可信应用的计量经济学基础

Event studies with panel data are widely used to estimate treatment effects. With repeated cross-sections, future treatment dates are unobserved for untreated individuals. Pseudo-panel event studies impute pre-treatment outcomes of the treated using matched untreated individuals. This paper establishes identification in such designs and characterizes bias when identification conditions fail. I show that the pseudo-panel regression is equivalent to weighted least squares with…

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When Treatments Spill Over: A Neural Framework for Spatiotemporal Causal Effect Estimation

当处理发生溢出:时空因果效应估计的神经网络框架

Real-world public health policies are often enacted by local jurisdictions, but their effects can ripple through connected populations. For causal evaluation, this creates a difficult spatiotemporal problem: intermittent policy updates create path-level treatments, and because spillover depends on neighboring treatment paths along with the focal-unit's own history, controlling time-varying confounding requires high-dimensional, multimodal information from both sources. To…

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Global Inference for High Dimensional Quantile Regression with Heterogeneity

异质性高维分位数回归的全局推断

Quantile regression has received considerable attention in high dimensional methodology due to its robustness and ability to accommodate heteroskedasticity. Despite this attention, current inferential methods for high dimensional quantile regression have significant limitations---only testing significance, testing at a single quantile at a time, or assuming homoskedasticity. To generalize the inferences that can be drawn in high dimensional quantile regression, we introduce…

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Nested Instrumental Variables Analysis: Switcher Average Treatment Effect, Identification, Efficient Estimation and Generalizability

嵌套工具变量分析:转换者平均处理效应及可推广性

Instrumental variables (IVs) are widely used to estimate causal effects from non-randomized data. A canonical example is a randomized trial with noncompliance, in which the randomized treatment assignment serves as an IV for the non-ignorable treatment received. Under a monotonicity assumption, a valid IV nonparametrically identifies the average treatment effect among a latent complier subgroup, whose generalizability is often under debate. In many studies, there exist…

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Debiased inference for proximal dose-response function

We study nonparametric inference for a continuous-treatment causal dose-response curve and its first derivative under unmeasured confounding, using treatment- and outcome-inducing proxies. We establish a proximal doubly robust pseudo-outcome whose conditional mean given treatment equals the dose-response curve whenever either bridge function is correctly specified. Their (smoothed) efficient influence function representations lead to cross-fitted local-polynomial estimators…

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Sharp bounds for within-household encouragement designs with interference

Experiments with spillovers create incentives for strategic behavior: when one household member's treatment can affect another, take-up decisions become interdependent. We propose an instrumental-variables framework grounded in game theory, in which take-up is a Nash equilibrium among a small number of agents, and all variables are discrete. Under minimal assumptions, without specifying how equilibria are selected, we derive sharp non-parametric bounds for direct, indirect,…

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Surrogate-powered Causal Inference with Censored Outcomes

利用辅助事件信息进行删失结局的因果推断

Clinical trials with survival endpoints lose information when participants are censored before death is observed. We develop target-preserving estimators that use posttreatment disease history, such as recurrence or progression, to recover information lost to censoring for marginal survival and restricted mean survival effects. The difficulty is that the intermediate event is downstream of treatment: naive adjustment can change the causal estimand, and the useful information…

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Matched Triple-Differences: A Framework for Covariate Adjustment

匹配三重差分:协变量调整框架

A common empirical strategy in triple-differences (DDD) is to include either covariate trends or covariate levels to a three-way fixed effects (3WFE) regression. This strategy is typically motivated by the conditional parallel gaps assumption which assumes that deviations from parallel trends are similar among units with comparable observed covariates. We formally study both 3WFE specifications and show that, in general, neither consistently estimates the average treatment…

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Bootstrap Inference with a Randomly Assigned Regressor: Covariance Filtering and the Limits of Marginal Resampling

随机分配回归变量的自助法推断:协方差过滤与边际重抽样的局限

Random assignment can make ordinary least squares (OLS) inference insensitive to outcome dependence, yet iid resampling can still fail because assignment and resampling need not remove the same covariance terms. With binary treatment, the iid variance target differs from the sampling variance by exactly minus aggregate cross-unit covariance of treatment effects. Under a Gaussian first-order limit, positive covariance leads to over-rejection and negative covariance to…

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Flexible Nonparametric Inference for Causal Effects under the Front-Door Model

前门模型下因果效应的灵活非参数推断

Evaluating causal treatment effects in observational studies requires addressing confounding. While the back-door criterion enables identification through adjustment for observed covariates, it fails in the presence of unmeasured confounding. The front-door criterion offers an alternative by leveraging variables that fully mediate the treatment effect and are unaffected by unmeasured confounders of the treatment-outcome pair. We develop novel one-step and targeted minimum…

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Pragmatic DML with AI-Learned Representations

使用 AI 学习表征的实用双重机器学习

Text, images, and other rich covariates are increasingly compressed into AI-learned representations and then used as controls in causal analysis. We study when this approach is valid and develop a practical framework for causal inference with learned representations. For a broad class of estimands, an imperfect representation distorts the target causal parameter by the product of two representation errors: one in the outcome regression and one in the balancing weight (or…

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Cheap subsampling bootstrap confidence intervals with applications to longitudinal causal inference

The bootstrap is widely used to construct confidence intervals but may perform poorly for some estimators. We consider semiparametric estimators that use cross-validation to estimate nuisance pa- rameters and can be computationally expensive in large datasets. We illustrate potential problems with bootstrapping with replacement when cross-validation is used and extend the cheap bootstrap confidence interval to subsampling without replacement for asymptotically linear…

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Imputation is all you need: double robustness, semiparametric efficiency, and automatic covariate balance for estimating the average treatment effect

插补就够了:平均处理效应估计的双稳健、半参数有效性与自动协变量平衡

Imputation-based causal estimation is typically viewed as relying exclusively on an outcome model, in contrast to augmented inverse-probability weighting, whose consistency is protected by fitting two nuisance models. This paper argues that this view can be misleading by highlighting a hidden dual weighting structure in least-squares sieve regression imputation. Although only outcome regressions are explicitly fitted, the resulting imputation estimator admits an exact…

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Characterizing Survivor Principal Strata Over Time: Identification, Efficient Estimation, and Sensitivity Analysis

随时间刻画幸存者主层:识别、有效估计与敏感性分析

Longitudinal studies with functional outcomes subject to truncation-by-death frequently report time-indexed survivor average causal effect estimates, defined among individuals who would survive regardless of treatment assignment. Because the survivor stratum can change over time, the resulting effect estimates may pertain to populations with different characteristics. We propose accompanying survivor average causal effect estimates with measures of covariate divergence…

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Debiased Machine Learning for Unobserved Heterogeneity: High-Dimensional Panels and Measurement Error Models

不可观测异质性的去偏机器学习:高维面板与测量误差模型

Developing robust inference for models with nonparametric Unobserved Heterogeneity (UH) is both important and challenging. We propose novel Debiased Machine Learning (DML) procedures for valid inference on functionals of UH, allowing for partial identification of multivariate target and high-dimensional nuisance parameters. Our main contribution is a full characterization of all relevant Neyman-orthogonal moments in models with nonparametric UH, where relevance means…

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Is the treatment beneficial? Causal Inference with Ordinal Outcomes: A Bayesian Solution

处理是否有益?有序结局因果推断的贝叶斯方法

Randomized experiments with ordinal outcomes are common across scientific applications, but conventional causal estimands such as the average treatment effect are difficult to interpret because ordinal categories lack meaningful numerical spacing. Two interpretable estimands, the probabilities that the treatment is beneficial and strictly beneficial, depend on the joint distribution of the potential outcomes and are therefore not identifiable from observed data. The sharp…

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Graph-Split Bayesian Causal Forest for Spatial Heterogeneous Treatment Effect Estimation

图分割贝叶斯因果森林:空间异质性处理效应估计

In spatial observational studies, treatment assignment and outcomes often exhibit spatial dependence patterns, and treatment effects may vary across space and subpopulations due to both measured and unmeasured spatially structured confounders. Accounting for spatial dependence while estimating heterogeneous treatment effects (HTEs) is a central task in spatial causal inference. Causal Bayesian additive regression tree methods are popular nonparametric methods for modeling…

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Nonparametric Identification and Estimation of Causal Effects on Latent Outcomes

潜在结果变量因果效应的非参数识别与估计

How should researchers conduct causal inference when the outcome of interest is latent and measured imperfectly by multiple indicators? We develop a general nonparametric framework for identifying and estimating average treatment effects on latent outcomes in randomized experiments. We show that latent-outcome estimation faces a fundamental but overlooked noncomparability problem due to measurement-set dependence: adding, removing, or replacing measurement targets a…

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Simple Specification-Free Causal Inference in Large Panels

大面板中的简洁、无需特定参数设定的因果推断

We propose a simple and transparent approach to causal inference using panel data with a large number of units and periods. Instead of imposing a particular parametric specification on the untreated potential outcomes, we assume they follow a nonparametric nonseparable factor model. We use long pre-treatment outcome histories to construct a measure of similarity between the latent factors of different units. Using this measure, we impute missing counterfactual means and…

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Difference-in-Differences Meets Synthetic Control: Doubly Robust Identification and Estimation

双重差分与合成控制的结合:双重稳健识别和估计

Difference-in-Differences (DiD) and Synthetic Control (SC) are widely used methods for causal inference in panel data, each with distinct strengths and limitations. We propose a novel method for short-panel causal inference that integrates the advantages of both approaches. Our method delivers a doubly robust identification strategy for the average treatment effect on the treated (ATT) under either of two non-nested assumptions: parallel trends or a group-level SC condition.…

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Identification and efficient estimation of compliance and network causal effects in cluster-randomized trials

整群随机试验中依从效应与网络因果效应的识别和有效估计

Treatment noncompliance is pervasive in infectious disease cluster-randomized trials. Although all individuals within a cluster are assigned the same treatment condition, the treatment uptake status may vary across individuals due to noncompliance. We propose a semiparametric framework to evaluate the individual compliance effect and network assignment effect within principal stratum exhibiting different patterns of noncompliance. The individual compliance effect captures…

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Sliced $L^p$ Distributional Balancing

切片 Lp 分布平衡方法

A popular class of causal inference methods addresses confounding through weighting, which reweights treated and control groups to balance their covariate distributions without using outcome information, thereby preserving a design-based perspective. In this paper, we propose sliced $L^p$ distributional balancing (SLDB), a family indexed by $p\in[1,\infty)$ that measures imbalance by averaging squared $L^p$ distances between the cumulative distribution functions of…

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