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随机试验的比较：试验参与效应与效应迁移AI 解读

Disagreements between randomized trials that address the same causal question pose challenges for the interpretation and synthesis of evidence. We sketch a causal framework for comparing the results of randomized trials that explicitly accommodates the possibility of trial engagement effects. Using counterfactual outcomes defined under joint interventions on treatment assignment and trial-related actions, we compare trial-native treatment effects with the effects transported…

将嵌套随机试验的条件平均处理效应推广至全部符合资格者AI 解读

Randomized controlled trials often enroll participants whose characteristics differ from those of a target population, which can limit the generalizability of the estimated treatment effects when effect modifiers differ across populations. While existing generalizability methods primarily focus on estimating the average treatment effect (ATE) in the target population, such summaries may obscure important heterogeneity that is relevant for clinical and policy decision-making.…

随机试验中分配对因果效应定义与识别的作用AI 解读

In randomized trials, the per-protocol effect, that is, the effect of being assigned a treatment strategy and receiving treatment according to the assigned strategy, is sometimes thought to reflect the effect of the treatment strategy itself, without intervention on assignment. Here, we argue by example that this is not necessarily the case. We examine a causal structure for a randomized trial where these two causal estimands -- the per-protocol effect and the effect of the…