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存在干扰时合成控制的稳健回归方法AI 解读

Synthetic control methods are widely used for policy evaluation, but most existing approaches rule out interference among units, compromising validity when such effects are present. We develop a framework that accommodates contaminated donor pools and unknown interference patterns through two stages: factor-model adjustment for unobserved confounding, followed by robust regression in which direct and interference effects appear as a sparse outlier component. We study two…

多重呼吸道检测时代如何选择检测阴性对照：因果视角AI 解读

The test-negative design (TND) is widely used to estimate vaccine effectiveness (VE) for respiratory pathogens by comparing vaccination odds among test-positive cases versus test-negative controls. A central yet underexplored design element is which test-negative illnesses constitute valid controls. With rapid multiplex PCR panels, investigators can now identify specific non-focal pathogens among test-negative patients, allowing for better characterization of ``test-negative…

监管试验协变量调整的良好实践：从固定到数据自适应方法AI 解读

While randomization justifies the use of unadjusted effect estimators in randomized trials, there is growing interest in covariate adjustment to improve precision. Adjusting for baseline variables that are prognostic of the outcome can reduce estimator variance, resulting in narrower confidence intervals and increased statistical power. Recent guidance by the U.S. Food and Drug Administration supports fixed adjustment for prognostic covariates using parametric regression…

估计处理效应异质性的目标联邦学习框架：稳健方法与老龄队列应用AI 解读

Analyzing data from multiple sources offers valuable opportunities to improve the estimation efficiency of causal estimands. However, this analysis also poses many challenges due to population heterogeneity and data privacy constraints. While several advanced methods for causal inference in federated settings have been developed in recent years, many focus on difference-based averaged causal effects and are not designed to study effect modification. In this study, we…

利用外部对照开展试验近端学习：HIV 预防案例AI 解读

With the advent of effective pre-exposure prophylaxis agents, active-controlled HIV prevention trials have become a common study design. Nevertheless, estimating absolute efficacy relative to a placebo remains important. In this paper, we introduce a novel application of proximal causal inference methods to estimate the counterfactual cumulative HIV incidence under placebo for participants in an active-controlled trial of cabotegravir, using external control data from a…

饮酒对脑白质微结构完整性的影响：不完整表型数据的因果推断框架AI 解读

Although substance use, such as alcohol intake, is known to be associated with cognitive decline during aging, its direct influence on the central nervous system remains incompletely understood. In this study, we investigate the influence of alcohol intake frequency on reduction of brain white matter microstructural integrity in the fornix, a brain region considered a promising marker of age-related microstructural degeneration, using a large UK Biobank (UKB) cohort with…

含部分无效代理变量的自适应近端因果推断AI 解读

Proximal causal inference (PCI) is a recently proposed framework to identify and estimate the causal effect of an exposure on an outcome in the presence of hidden confounders, using observed proxies. Specifically, PCI relies on two types of proxies: a treatment-inducing confounding proxy, related to the outcome only through its association with unmeasured confounders (given treatment and covariates), and an outcome-inducing confounding proxy, related to the treatment only…

容许多个无效代理变量的强化近端因果推断AI 解读

Causal inference from observational data often relies on the assumption of no unmeasured confounding, an assumption frequently violated in practice due to unobserved or poorly measured covariates. Proximal causal inference (PCI) offers a promising framework for addressing unmeasured confounding using a pair of outcome and treatment confounding proxies. However, existing PCI methods typically assume all specified proxies are valid, which may be unrealistic and is untestable…

多种检测原因下的检测阴性设计：统计偏差与解决方法AI 解读

Test-negative designs are widely used for post-market evaluation of vaccine effectiveness, particularly in cases when randomized trials are not feasible. Differing from classical test-negative designs where only healthcare-seekers with symptoms are included, recent test-negative designs have involved individuals with various reasons for testing, especially in an outbreak setting. While including these data can increase sample size and hence improve precision, concerns have…

右删失事件时间数据的回归型近端因果推断AI 解读

Unmeasured confounding is one of the major concerns in causal inference from observational data. Proximal causal inference (PCI) is an emerging methodological framework to detect and potentially account for confounding bias by carefully leveraging a pair of negative control exposure (NCE) and outcome (NCO) variables, also known as treatment and outcome confounding proxies. Although regression-based PCI is well developed for binary and continuous outcomes, analogous PCI…

双重稳健的近端合成控制AI 解读

To infer the treatment effect for a single treated unit using panel data, synthetic control methods construct a linear combination of control units' outcomes that mimics the treated unit's pre-treatment outcome trajectory. This linear combination is subsequently used to impute the counterfactual outcomes of the treated unit had it not been treated in the post-treatment period, and used to estimate the treatment effect. Existing synthetic control methods rely on correctly…

惩罚化偏差缩减的双重稳健因果推断：融合非概率样本与设计调查AI 解读

Causal inference on the average treatment effect (ATE) using non-probability samples, such as electronic health records (EHR), faces challenges from sample selection bias and high-dimensional covariates. This requires considering a selection model alongside treatment and outcome models that are typical ingredients in causal inference. This paper considers integrating large non-probability samples with external probability samples from a design survey, addressing moderately…

合成控制的识别与推断：近端因果推断框架AI 解读

Synthetic control (SC) methods are commonly used to estimate the treatment effect on a single treated unit in panel data settings. An SC is a weighted average of control units built to match the treated unit, with weights typically estimated by regressing (summaries of) pre-treatment outcomes and measured covariates of the treated unit to those of the control units. However, it has been established that in the absence of a good fit, such regression estimator will generally…

DANCE：数据驱动的负对照搜索、验证与因果估计AI 解读

Negative control variables are increasingly used to adjust for unmeasured confounding bias in causal inference using observational data. They are typically identified by subject matter knowledge and there is currently a severe lack of data-driven methods to find negative controls. In this paper, we present a statistical test for discovering negative controls of a special type -- disconnected negative controls -- that can serve as surrogates of the unmeasured confounder, and…

复杂纵向研究中的近端因果推断AI 解读

A standard assumption for causal inference about the joint effects of time-varying treatment is that one has measured sufficient covariates to ensure that within covariate strata, subjects are exchangeable across observed treatment values, also known as "sequential randomization assumption (SRA)". SRA is often criticized as it requires one to accurately measure all confounders. Realistically, measured covariates can rarely capture all confounders with certainty. Often…

混杂性结局依赖抽样下的双重稳健近端因果推断AI 解读

Unmeasured confounding and selection bias are often of concern in observational studies and may invalidate a causal analysis if not appropriately accounted for. Under outcome-dependent sampling, a latent factor that has causal effects on the treatment, outcome, and sample selection process may cause both unmeasured confounding and selection bias, rendering standard causal parameters unidentifiable without additional assumptions. Under an odds ratio model for the treatment…

分布式数据共享管理下的协作因果推断AI 解读

Data sharing barriers are paramount challenges arising from multicenter clinical trials where multiple data sources are stored in a distributed fashion at different local study sites. Merging such data sources into a common data storage for a centralized statistical analysis requires a data use agreement, which is often time-consuming. Data merging may become more burdensome when causal inference is of primary interest because propensity score modeling involves combining…

在线因果推断及其在近实时疫苗上市后安全监测中的应用AI 解读

Streaming data routinely generated by mobile phones, social networks, e-commerce, and electronic health records present new opportunities for near real-time surveillance of the impact of an intervention on an outcome of interest via causal inference methods. However, as data grow rapidly in volume and velocity, storing and combing data become increasingly challenging. The amount of time and effort spent to update analyses can grow exponentially, which defeats the purpose of…

因果推断中的数据整合AI 解读

Integrating data from multiple heterogeneous sources has become increasingly popular to achieve a large sample size and diverse study population. This paper reviews development in causal inference methods that combines multiple datasets collected by potentially different designs from potentially heterogeneous populations. We summarize recent advances on combining randomized clinical trial with external information from observational studies or historical controls, combining…