A multistate approach for mediation analysis in the presence of semi-competing risks with application in cancer survival disparities
半竞争风险下中介分析的多状态方法及癌症生存差异应用
We propose a novel methodology to quantify the effect of stochastic interventions on non-terminal time-to-events that lie on the pathway between an exposure and a terminal time-to-event outcome. Investigating these effects is particularly important in health disparities research when we seek to quantify inequities in timely delivery of treatment and its impact on patients survival time. Current approaches fail to account for semi-competing risks arising in this setting.…