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行政删失下利用短期替代指标半参数估计延迟结果处理效应AI 解读

The multi-site registry studies, such as Stepped-wedge cluster-randomized trials (SW-CRT), staggered-enrollment RCTs, etc., share a structural feature: the primary long-term outcome is administratively censored for a non-negligible fraction of units, with censoring driven by calendar design rather than by the outcome itself. Standard inverse-probability-of-censoring weighting becomes unstable when observation probabilities $g_Δ$ concentrate near zero for late-crossing units,…

连续处理的多变量增量效应：环境混合暴露的健康影响AI 解读

Evaluating the causal health effects of multivariate, continuous exposures, such as air pollution mixtures, is a critical public health challenge. A primary obstacle is the frequent violation of the positivity assumption, which renders the effects of standard deterministic interventions unidentified or heavily reliant on unreliable model extrapolation. In this paper, we develop a novel causal inference framework to address this challenge. We extend exponential tilting to…

为何因果推断的双重稳健估计量在方差估计上并非双重稳健AI 解读

Doubly robust estimators (DRE) are widely used in causal inference because they yield consistent estimators of average causal effect when at least one of the nuisance models, the propensity for treatment (exposure) or the outcome regression, is correct. However, double robustness does not extend to variance estimation; the influence-function (IF)-based variance estimator is consistent only when both nuisance parameters are correct. This raises concerns about applying DRE in…

观察研究因果推断中 Mann–Whitney–Wilcoxon 秩和统计量的双重稳健估计AI 解读

The Mann-Whitney-Wilcoxon rank sum test (MWWRST) is a widely used method for comparing two treatment groups in randomized control trials, particularly when dealing with highly skewed data. However, when applied to observational study data, the MWWRST often yields invalid results for causal inference. To address this limitation, Wu et al. (2014) introduced an approach that incorporates inverse probability weighting (IPW) into this rank-based statistics to mitigate confounding…