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慢性肾病分层复合终点分析中胜率比的解释难题AI 解读

Win statistics based methods have gained traction as a method for analyzing Hierarchical Composite Endpoints (HCEs) in randomized clinical trials, particularly in cardiovascular and kidney disease research. HCEs offer several key advantages, including increased statistical power, mitigation of competing risks, and hierarchical ranking of clinical outcomes. While, as summary measures, the win ratio (WR) along with the Net Benefit (NB) and the Win Odds (WO) provide a…

估计纵向替代结局治疗效应的半参数联合模型：慢性肾病试验应用AI 解读

In clinical trials where long follow-up is required to measure the primary outcome of interest, there is substantial interest in using an accepted surrogate outcome that can be measured earlier in time or with less cost to estimate a treatment effect. For example, in clinical trials of chronic kidney disease (CKD), the effect of a treatment is often demonstrated on a surrogate outcome, the longitudinal trajectory of glomerular filtration rate (GFR). However, estimating the…