Conditional Inference for Secondary Outcomes Based on the Testing Result for the Primary Outcome in Clinical Trials
基于临床试验主要结局检验结果的次要结局条件推断
In clinical trials, inferences on clinical outcomes are often made conditional on specific selective processes. For instance, only when a treatment demonstrates a significant effect on the primary outcome, further analysis is conducted to investigate its efficacy on selected secondary outcomes. Similarly, inferences may also depend on whether a trial is terminated early at interim stage. While conventional approaches primarily aim to control the family-wise error rate…