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面向微生物组计数的贝叶斯非参数纵向因子模型AI 解读

Longitudinal microbiome studies provide important insights into the temporal evolution of microbial abundances and dynamic cross-feature dependence. Modeling longitudinal microbiome data is challenging because microbiome counts are highly heterogeneous and zero-inflated, and, moreover, repeated measurements induce within-subject temporal dependence and possibly time-varying cross-feature covariance. To address these challenges, we develop a flexible Bayesian longitudinal…

多变量计数数据的贝叶斯协变量变化交互分析：微生物组应用AI 解读

Understanding covariate-varying interdependencies among features is of great interest in various applications. Motivated by microbiome studies where microbial abundances and interactions vary with environmental factors, we develop a Bayesian covariate-varying factor model. This model flexibly estimates heteroscedasticity in the covariance matrix as a function of covariates. Specifically, our approach employs covariance regression through linear regression on a…