Learning Massive-scale Partial Correlation Networks in Clinical Multi-omics Studies with HP-ACCORD
HP-ACCORD:临床多组学研究中的大规模偏相关网络学习
Graphical model estimation from multi-omics data requires a balance between statistical estimation performance and computational scalability. We introduce a novel pseudolikelihood-based graphical model framework that reparameterizes the target precision matrix while preserving the sparsity pattern and estimates it by minimizing an $\ell_1$-penalized empirical risk based on a new loss function. The proposed estimator maintains estimation and selection consistency in various…