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阶梯楔形整群随机试验中总体与亚组因果效应的校准贝叶斯推断AI 解读

Stepped-wedge cluster-randomized trials (SW-CRTs) randomly assign clusters to sequences that determine when each cluster switches from control to intervention. Conventional Bayesian analyses of SW-CRTs report treatment effect coefficients from a working outcome model, but under model misspecification or informative cluster-period sizes, such coefficients can lack a clear causal interpretation. In this work, we develop Bayesian methods targeting weighted average treatment…

整群随机试验的校准贝叶斯分析AI 解读

In cluster-randomized trials (CRTs), entire clusters of individuals are randomized to treatment, and outcomes within a cluster are typically correlated. While frequentist approaches are standard practice for CRT analysis, Bayesian methods have emerged as a strong alternative. Previous work has investigated the use of Bayesian hierarchical models for continuous, binary, and count outcomes in CRTs, but these approaches focus on model-based treatment effect coefficients as the…

具有连续效果与实施终点的二型混合整群随机试验设计方法比较AI 解读

Hybrid type 2 studies are gaining popularity for their ability to assess both implementation and health outcomes as co-primary endpoints. Often conducted as cluster-randomized trials (CRTs), five design methods can validly power these studies: p-value adjustment methods, combined outcomes approach, single weighted 1-DF test, disjunctive 2-DF test, and conjunctive test. We compared these methods theoretically and numerically. Theoretical comparisons of power equations allowed…