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Missingness in variables that define study eligibility criteria is a seldom addressed challenge in electronic health record (EHR)-based settings. Patients with incomplete eligibility information are typically excluded from analysis without consideration of the (implicit) assumptions being made, leaving study conclusions subject to potential selection bias. In an effort to ascertain eligibility for more patients, researchers may look back further in time prior to study…

双重稳健泛函最优估计中的辅助函数调参与样本分割AI 解读

Estimators of doubly robust functionals typically rely on estimating two complex nuisance functions, such as the propensity score and conditional outcome mean for the average treatment effect functional. We consider the problem of how to estimate nuisance functions to obtain optimal rates of convergence for a doubly robust nonparametric functional that has witnessed applications across the causal inference and conditional independence testing literature. For several plug-in…

电子健康记录研究中随治疗启动时间变化的因果效应框架AI 解读

Standard practice in electronic health record (EHR)-based studies evaluating the comparative effectiveness of bariatric surgery relative to no surgery is to estimate and report a constant treatment effect across calendar time. However, real-world treatment strategies can evolve, particularly when comparators include standard of care or surgical procedures where techniques may improve, making it clinically important to ascertain whether efficacy of bariatric surgery has…

半参数有效的经验高阶影响函数估计量AI 解读

Robins et al. (2008, 2017) applied the theory of higher order influence functions (HOIFs) to derive an estimator of the mean $ψ$ of an outcome Y in a missing data model with Y missing at random conditional on a vector X of continuous covariates; their estimator, in contrast to previous estimators, is semiparametric efficient under the minimal conditions of Robins et al. (2009b), together with an additional (non-minimal) smoothness condition on the density g of X, because the…

比例渐近下双重稳健泛函估计的最优干扰函数调参AI 解读

In this paper, we explore the asymptotically optimal tuning parameter choice in ridge regression for estimating nuisance functions of a statistical functional that has recently gained prominence in conditional independence testing and causal inference. Given a sample of size $n$, we study estimators of the Expected Conditional Covariance (ECC) between variables $Y$ and $A$ given a high-dimensional covariate $X \in \mathbb{R}^p$. Under linear regression models for $Y$ and $A$…

比例渐近下广义线性模型与双重稳健泛函的矩估计推断AI 解读

In this paper, we consider the estimation of regression coefficients and signal-to-noise (SNR) ratio in high-dimensional Generalized Linear Models (GLMs), and explore their implications in inferring popular estimands such as average treatment effects in high-dimensional observational studies. Under the ``proportional asymptotic'' regime and Gaussian covariates with known (population) covariance $Σ$, we derive Consistent and Asymptotically Normal (CAN) estimators of our…

通过双重抽样处理缺失数据的因果分位数处理效应AI 解读

Causal weighted quantile treatment effects (WQTE) are a useful complement to standard causal contrasts that focus on the mean when interest lies at the tails of the counterfactual distribution. To-date, however, methods for estimation and inference regarding causal WQTEs have assumed complete data on all relevant factors. In most practical settings, however, data will be missing or incomplete data, particularly when the data are not collected for research purposes, as is the…

具有成对依赖的马尔可夫随机场中的伪关联AI 解读

Yule (1926) identified the issue of "nonsense correlations" in time series data, where dependence within each of two random vectors causes overdispersion -- i.e. variance inflation -- for measures of dependence between the two. During the near century since then, much has been written about nonsense correlations -- but nearly all of it confined to the time series literature. In this paper we provide the first, to our knowledge, rigorous study of this phenomenon for more…

电子健康记录比较效果研究中信息性缺失数据的双重抽样AI 解读

Missing data arise in most applied settings and are ubiquitous in electronic health records (EHR). When data are missing not at random (MNAR) with respect to measured covariates, sensitivity analyses are often considered. These post-hoc solutions, however, are often unsatisfying in that they are not guaranteed to yield concrete conclusions. Motivated by an EHR-based study of long-term outcomes following bariatric surgery, we consider the use of double sampling as a means to…

增广逆概率加权估计量的新中心极限定理：方差膨胀与交叉拟合协方差AI 解读

Estimation of the average treatment effect (ATE) is a central problem in causal inference. In recent times, inference for the ATE in the presence of high-dimensional covariates has been extensively studied. Among the diverse approaches that have been proposed, augmented inverse probability weighting (AIPW) with cross-fitting has emerged a popular choice in practice. In this work, we study this cross-fit AIPW estimator under well-specified outcome regression and propensity…

处理与结果仅部分标注时平均处理效应的高效稳健半监督估计AI 解读

A notable challenge of leveraging Electronic Health Records (EHR) for treatment effect assessment is the lack of precise information on important clinical variables, including the treatment received and the response. Both treatment information and response often cannot be accurately captured by readily available EHR features and require labor intensive manual chart review to precisely annotate, which limits the number of available gold standard labels on these key variables.…