Mapping beyond diseases: Controlled variable selection for secondary phenotypes using tilted knockoffs
超越疾病研究:用倾斜 knockoffs 控制次级表型变量选择
Researchers in biomedical studies often work with samples that are not selected uniformly at random from the population of interest, a major example being a case-control study. While these designs are motivated by specific scientific questions, it is often of interest to use the data collected to pursue secondary lines of investigations. In these cases, ignoring the fact that observations are not sampled uniformly at random can lead to spurious results. For example, in a…