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外部验证研究中回归校准测量误差校正的可迁移性AI 解读

In nutritional and environmental epidemiology, exposures are impractical to measure accurately, while practical measures for these exposures are often subject to substantial measurement error. Regression calibration is among the most used measurement error correction methods with external validation studies. The use of external studies to assess the measurement error process always carries the risk of introducing estimation bias into the main study analysis. Although the…

暴露测量误差插补型回归校准的因果协变量选择AI 解读

In this paper, we identify the criteria for the selection of the minimal and most efficient covariate adjustment sets for the regression calibration method developed by Carroll, Rupert and Stefanski (CRS, 1992), used to correct bias due to continuous exposure measurement error. We utilize directed acyclic graphs to illustrate how subject matter knowledge can aid in the selection of such adjustment sets. Valid measurement error correction requires the collection of data on…

连续暴露测量误差下回归校准的因果协变量选择AI 解读

Regression calibration as developed by Rosner, Spiegelman and Willet is used to correct the bias in effect estimates due to measurement error in continuous exposures. The method involves two models: a measurement error model (MEM) relating the mismeasured exposure to the true exposure and an outcome model relating the mismeasured exposure to outcome. However, no comprehensive guidance exists for determining which covariates should be included in each model. In this paper, we…

异质性疾病病因中的无其他亚型平均因果效应AI 解读

Studies have shown that the effect an exposure may have on a disease can vary for different subtypes of the same disease. However, existing approaches to estimate and compare these effects largely overlook causality. In this paper, we study the effect smoking may have on having colorectal cancer subtypes defined by a trait known as microsatellite instability (MSI). We use principal stratification to propose an alternative causal estimand, the Subtype-Free Average Causal…