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整群随机试验中处理死亡截断的加权方法AI 解读

Patient-centered outcomes, such as quality of life and length of hospital stay, are the focus in a wide array of clinical studies. However, participants in randomized trials for elderly or critically and severely ill patient populations may have truncated or undefined non-mortality outcomes if they do not survive through the measurement time point. To address truncation by death, the survivor average causal effect (SACE) has been proposed as a causally interpretable subgroup…

厘清整群随机试验中的估计目标AI 解读

Estimands can help clarify the interpretation of treatment effects and ensure that estimators are aligned to the study's objectives. Cluster randomised trials require additional attributes to be defined within the estimand compared to individually randomised trials, including whether treatment effects are marginal or cluster specific, and whether they are participant or cluster average. In this paper, we provide formal definitions of estimands encompassing both these…