A comparison of methods for designing hybrid type 2 cluster-randomized trials with continuous effectiveness and implementation endpoints
具有连续效果与实施终点的二型混合整群随机试验设计方法比较
Hybrid type 2 studies are gaining popularity for their ability to assess both implementation and health outcomes as co-primary endpoints. Often conducted as cluster-randomized trials (CRTs), five design methods can validly power these studies: p-value adjustment methods, combined outcomes approach, single weighted 1-DF test, disjunctive 2-DF test, and conjunctive test. We compared these methods theoretically and numerically. Theoretical comparisons of power equations allowed…