Approximating the Operating Characteristics of Bayesian Uncertainty Directed Trial Designs
贝叶斯不确定性导向试验设计运行特征的近似
Bayesian response adaptive clinical trials are currently evaluating experimental therapies for several diseases. Adaptive decisions, such as pre-planned variations of the randomization probabilities, attempt to accelerate the development of new treatments. The design of response adaptive trials, in most cases, requires time consuming simulation studies to describe operating characteristics, such as type I/II error rates, across plausible scenarios. We investigate large…