Using modified intention-to-treat as a principal stratum estimator for failure to initiate treatment
将排除未启动治疗者的修正意向治疗分析解释为主层估计
Background: A common intercurrent event affecting many trials is when some participants do not begin their assigned treatment. Many trials use a modified intention-to-treat (mITT) approach, whereby participants who do not initiate treatment are excluded from the analysis. However, it is not clear the estimand being targeted by such an approach or the assumptions necessary for it to be unbiased. Methods: We demonstrate that a mITT analysis which excludes participants who do…