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Variance estimation after matching or re-weighting

匹配或重新加权后的方差估计

This paper develops a variance estimation framework for matching estimators that enables valid population inference for treatment effects. We provide theoretical analysis of a variance estimator that addresses key limitations in the existing literature. While Abadie and Imbens (2006) proposed a foundational variance estimator requiring matching for both treatment and control groups, this approach is computationally prohibitive and rarely used in practice. Our method provides…

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Caliper Synthetic Matching: Generalized Radius Matching with Local Synthetic Controls

卡尺合成匹配:结合局部合成控制的广义半径匹配

Matching promises transparent causal inferences for observational data, making it an intuitive approach for many applications. In practice, however, standard matching methods often perform poorly compared to modern approaches such as response-surface modeling and optimizing balancing weights. We propose Caliper Synthetic Matching (CSM) to address these challenges while preserving simple and transparent matches and match diagnostics. CSM extends Coarsened Exact Matching by…

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More power to you: Using machine learning to augment human coding for more efficient inference in text-based randomized trials

用机器学习辅助人工编码,提高文本随机试验的推断效率

For randomized trials that use text as an outcome, traditional approaches for assessing treatment impact require that each document first be manually coded for constructs of interest by trained human raters. This process, the current standard, is both time-consuming and limiting: even the largest human coding efforts are typically constrained to measure only a small set of dimensions across a subsample of available texts. In this work, we present an inferential framework…

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Leveraging text data for causal inference using electronic health records

利用电子健康记录文本支持因果推断

In studies that rely on data from electronic health records (EHRs), unstructured text data such as clinical progress notes offer a rich source of information about patient characteristics and care that may be missing from structured data. Despite the prevalence of text in clinical research, these data are often ignored for the purposes of quantitative analysis due their complexity. This paper presents a unified framework for leveraging text data to support causal inference…

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Improving the Estimation of Site-Specific Effects and their Distribution in Multisite Trials

改进多地点试验中地点特定效应及其分布的估计

In multisite trials, researchers are often interested in several inferential goals: estimating treatment effects for each site, ranking these effects, and studying their distribution. This study seeks to identify optimal methods for estimating these targets. Through a comprehensive simulation study, we assess two strategies and their combined effects: semiparametric modeling of the prior distribution, and alternative posterior summary methods tailored to minimize specific…

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Benefits and costs of matching prior to a Difference in Differences analysis when parallel trends does not hold

平行趋势不成立时,双重差分分析前匹配的收益与成本

The Difference in Difference (DiD) estimator is a popular estimator built on the "parallel trends" assumption, which is an assertion that the treatment group, absent treatment, would change "similarly" to the control group over time. To bolster such a claim, one might generate a comparison group, via matching, that is similar to the treated group with respect to pre-treatment outcomes and/or pre-treatment covariates. Unfortunately, as has been previously pointed out, this…

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Empirical Bayes Double Shrinkage for Combining Biased and Unbiased Causal Estimates

结合有偏与无偏因果估计的经验贝叶斯双重收缩

Motivated by the proliferation of observational datasets and the need to integrate non-randomized evidence with randomized controlled trials, causal inference researchers have recently proposed several new methodologies for combining biased and unbiased estimators. We contribute to this growing literature by developing a new class of estimators for the data-combination problem: double-shrinkage estimators. Double-shrinkers first compute a data-driven convex combination of…

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Randomization Inference beyond the Sharp Null: Bounded Null Hypotheses and Quantiles of Individual Treatment Effects

超越尖锐零假设的随机化推断:有界零假设与个体处理效应分位数

Randomization inference (RI) is typically interpreted as testing Fisher's "sharp" null hypothesis that all unit-level effects are exactly zero. This hypothesis is often criticized as restrictive and implausible, making its rejection scientifically uninteresting. We show, however, that many randomization tests are also valid for a "bounded" null hypothesis under which the unit-level effects are all non-positive (or all non-negative) but are otherwise heterogeneous. In…

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Designing Experiments Toward Shrinkage Estimation

面向收缩估计的实验设计

We consider how increasingly available observational data can be used to improve the design of randomized controlled trials (RCTs). We seek to design a prospective RCT, with the intent of using an Empirical Bayes estimator to shrink the causal estimates from our trial toward causal estimates obtained from an observational study. We ask: how might we design the experiment to better complement the observational study in this setting? We propose using an estimator that shrinks…

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Leveraging Population Outcomes to Improve the Generalization of Experimental Results

利用总体结果数据提升实验结论的推广效率

Generalizing causal estimates in randomized experiments to a broader target population is essential for guiding decisions by policymakers and practitioners in the social and biomedical sciences. While recent papers developed various weighting estimators for the population average treatment effect (PATE), many of these methods result in large variance because the experimental sample often differs substantially from the target population, and estimated sampling weights are…

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Is it who you are or where you are? Accounting for compositional differences in cross-site treatment variation

是个体构成还是所在环境?分解跨站点处理效应差异

Multisite trials, in which treatment is randomized separately in multiple sites, offer a unique opportunity to disentangle treatment effect variation due to "compositional" differences in the distributions of unit-level features from variation due to "contextual" differences in site-level features. In particular, if we can re-weight (or "transport") each site to have a common distribution of unit-level covariates, the remaining effect variation captures contextual…

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