Interaction tests with covariate-adaptive randomization
协变量自适应随机化下的交互效应检验
Treatment-covariate interaction tests are commonly applied by researchers to examine whether the treatment effect varies across patient subgroups defined by baseline characteristics. The objective of this study is to explore treatment-covariate interaction tests involving covariate-adaptive randomization. Without assuming a parametric data generating model, we investigate usual interaction tests and observe that they tend to be conservative: specifically, their limiting…