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随时间刻画幸存者主层：识别、有效估计与敏感性分析AI 解读

Longitudinal studies with functional outcomes subject to truncation-by-death frequently report time-indexed survivor average causal effect estimates, defined among individuals who would survive regardless of treatment assignment. Because the survivor stratum can change over time, the resulting effect estimates may pertain to populations with different characteristics. We propose accompanying survivor average causal effect estimates with measures of covariate divergence…

多个误分类暴露的因果推断：控制变量调整的校准加权方法AI 解读

Exposure misclassification is a common issue prevalent in studies of respiratory infections in cystic fibrosis. Throat swabs are frequently used in place of expectorated or induced sputum cultures, although they have imperfect sensitivity and specificity to detect Pseudomonas aeruginosa and Staphylococcus aureus. We develop calibration weighting and control variate estimators for causal inference with multiple misclassified binary exposures and clustered observations. The…

两阶段抽样下结局与处理均有测量误差的高效因果效应估计AI 解读

Measurement error is a common challenge for causal inference studies using electronic health record (EHR) data, where clinical outcomes and treatments are frequently mismeasured. Researchers often address measurement error by conducting manual chart reviews to validate measurements in a subset of the full EHR data -- a form of two-phase sampling. To improve efficiency, phase-two samples are often collected in a biased manner dependent on the patients' initial, error-prone…

含暴露测量误差的灵活高效因果效应估计：控制变量法AI 解读

Exposure measurement error is a ubiquitous but often overlooked challenge in causal inference with observational data. Existing methods accounting for exposure measurement error largely rely on restrictive parametric assumptions, while emerging data-adaptive estimation approaches allow for less restrictive assumptions but at the cost of flexibility, as they are typically tailored towards rigidly-defined statistical quantities. There remains a critical need for…