Analysis of stepped wedge cluster randomized trials in the presence of a time-varying treatment effect
处理效应随暴露时间变化时的阶梯楔形整群随机试验分析
Stepped wedge cluster randomized controlled trials are typically analyzed using models that assume the full effect of the treatment is achieved instantaneously. We provide an analytical framework for scenarios in which the treatment effect varies as a function of exposure time (time since the start of treatment) and define the "effect curve" as the magnitude of the treatment effect on the linear predictor scale as a function of exposure time. The "time-averaged treatment…