Analysis of Stepped-Wedge Cluster Randomized Trials when treatment effects vary by exposure time or calendar time
处理效应随暴露时间或日历时间变化时的阶梯楔形整群随机试验分析
Stepped-wedge cluster randomized trials (SW-CRTs) are traditionally analyzed with models that assume an immediate and sustained treatment effect. Previous work has shown that making such an assumption in the analysis of SW-CRTs when the true underlying treatment effect varies by exposure time can produce severely misleading estimates. Alternatively, the true underlying treatment effect might vary by calendar time. Comparatively less work has examined treatment effect…