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利用非二元工具变量估计平均处理效应AI 解读

Non-binary instrumental variables, especially continuous ones, are common in practice. A binary recoding induces a Wald ratio but may discard useful variation and reduce efficiency. Although fully nonparametric approaches can in principle use the entire instrument, they often require high-dimensional nuisance estimation which can be unstable with rich covariates. We address this problem by developing a generalized Wald estimand for binary treatments that uses the full…

总体异质性下双样本孟德尔随机化的稳健框架AI 解读

Mendelian randomization is a powerful tool for causal inference in observational studies. The two-sample summary-data design, which estimates genetic associations with exposures and outcomes in separate cohorts, is the most widely used Mendelian randomization approach in large-scale genomic studies. However, this approach relies on a strong assumption of population homogeneity across the two samples. In practice, available samples often differ in ancestry, demographics,…

合成工具变量：从稀疏关联到稀疏因果效应AI 解读

In many observational studies, researchers are often interested in studying the effects of multiple exposures on a single outcome. Standard approaches for high-dimensional data such as the lasso assume the associations between the exposures and the outcome are sparse. These methods, however, do not estimate the causal effects in the presence of unmeasured confounding. In this paper, we consider an alternative approach that assumes the causal effects in view are sparse. We…