Clarifying identification and estimation of treatment effects in the Sequential Parallel Comparison Design
厘清序贯平行比较设计中治疗效应的识别与估计
Sequential parallel comparison design (SPCD) clinical trials aim to adjust active treatment effect estimates for placebo response to minimize the impact of placebo responders on the estimates. This is potentially accomplished using a two stage design by measuring treatment effects among all participants during the first stage, then classifying some placebo arm participants as placebo non-responders who will be re-randomized in the second stage. In this paper, we use causal…