Bayesian analysis of restricted mean survival time adjusted for covariates using pseudo-observations
利用伪观测进行协变量调整的限制平均生存时间贝叶斯分析
The difference in restricted mean survival time (RMST) is a clinically meaningful measure to quantify treatment effect in randomized controlled trials, especially when the proportional hazards assumption does not hold. Several frequentist methods exist to estimate RMST adjusted for covariates based on modeling and integrating the survival function. A more natural approach may be a regression model on RMST using pseudo-observations, which allows for a direct estimation…