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时变暴露下的工具变量：血运重建对生活质量的动态效应AI 解读

This paper develops instrumental variables (IV) estimators for dynamic causal effects in randomized trials with imperfect compliance. These methods are applied to a randomized trial that assigned patients with ischemic heart disease to either an invasive treatment arm centered on revascularization or a control group meant to receive non-invasive medical therapy. As is common in such ``strategy trials,'' many participants assigned to treatment remained untreated while many…

R.O.A.D.：通向临床试验模拟的框架AI 解读

Observational studies provide the only evidence on the effectiveness of interventions when randomized controlled trials (RCTs) are impractical due to cost, ethical concerns, or time constraints. While many methodologies aim to draw causal inferences from observational data, there is a growing trend to model observational study designs after RCTs, a strategy known as "target trial emulation." Despite its potential, causal inference through target trial emulation cannot fully…