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Gamma–Gamma与对数正态–Rician湍流信道的高斯化参数估计AI 解读

Accurate parameter estimation for atmospheric turbulence channels is challenging because the probability density functions of the Gamma-Gamma (GG) and Lognormal-Rician (LR) models involve special functions and numerical integrations. This paper proposes two Gaussianization parameter estimators for GG and LR turbulence channels, i.e., the quantile-transformation (QT) estimator and the Box-Cox estimator. The QT estimator employs bidirectional cross-transformation together with…

观察研究因果推断的样本量与功效计算AI 解读

This paper investigates the theoretical foundation and develops analytical formulas for sample size and power calculations for causal inference with observational data. By analyzing the variance of an inverse probability weighting estimator of the average treatment effect, we decompose the power calculation into three components: propensity score distribution, potential outcome distribution, and their correlation. We show that to determine the minimal sample size of an…

事件时间结局因果推断的样本量与功效计算AI 解读

This paper develops power and sample size formulas for causal inference with time-to-event outcomes. The target estimand is the marginal hazard ratio: the coefficient of a marginal structural Cox proportional hazard model with treatment as the only predictor. We extend the robust sandwich variance theory and derive the analytical form of the asymptotic variance for the inverse probability weighted partial likelihood estimator. Building on this, we derive a new analytical…

迈向准确且可解释的时间序列预测：多项式学习方法AI 解读

Time series forecasting enables early warning and has driven asset performance management from traditional planned maintenance to predictive maintenance. However, the lack of interpretability in forecasting methods undermines users' trust and complicates debugging for developers. Consequently, interpretable time-series forecasting has attracted increasing research attention. Nevertheless, existing methods suffer from several limitations, including insufficient modeling of…

治疗不依从下因果生存分析的多重稳健估计AI 解读

Comparative effectiveness research frequently addresses a time-to-event outcome and can require unique considerations in the presence of treatment noncompliance. Motivated by the challenges in addressing noncompliance in the ADAPTABLE pragmatic clinical trial, we develop a multiply robust estimator to estimate the principal survival causal effects under the principal ignorability and monotonicity. The multiply robust estimator is consistent even if one, and sometimes two, of…

临床试验中利用外部对照：目标量、估计与假设AI 解读

It is increasingly common to augment randomized controlled trial with external controls from observational data, to evaluate the treatment effect of an intervention. Traditional approaches to treatment effect estimation involve ambiguous estimands and unrealistic or strong assumptions, such as mean exchangeability. We introduce a double-indexed notation for potential outcomes to define causal estimands transparently and clarify distinct sources of implicit bias. We show that…

通过加权处理整群随机试验中的选择偏差AI 解读

In cluster randomized experiments, individuals are often recruited after the cluster treatment assignment, and data are typically only available for the recruited sample. Post-randomization recruitment can lead to selection bias, inducing systematic differences between the overall and the recruited populations, and between the recruited intervention and control arms. In this setting, we define causal estimands for the overall and the recruited populations. We prove, under…

PStrata：用于主分层分析的 R 软件包AI 解读

Post-treatment confounding is a common problem in causal inference, including special cases of noncompliance, truncation by death, surrogate endpoint, etc. Principal stratification (Frangakis and Rubin 2002) is a general framework for defining and estimating causal effects in the presence of post-treatment confounding. A prominent special case is the instrumental variable approach to noncompliance in randomized experiments (Angrist, Imbens, and Rubin 1996). Despite its…

事件时间结局的主分层分析AI 解读

Post-randomization events, also known as intercurrent events, such as treatment noncompliance and censoring due to a terminal event, are common in clinical trials. Principal stratification is a framework for causal inference in the presence of intercurrent events. Despite the extensive existing literature, there lacks generally applicable and accessible methods for principal stratification analysis with time-to-event outcomes. In this paper, we specify two causal estimands…