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人口干预中间接效应与干预变量效应的近端推断AI 解读

Unmeasured confounding, unethical exposure, and ill-defined interventions pose significant challenges to evaluating policy-relevant mediation estimands in medicine and public health. In observational studies involving harmful exposures, the population intervention indirect effect (PIIE) is often more salient than the natural indirect effect, as the latter relies on hypothetical interventions that may be ethically or practically unfeasible. While the PIIE can be identified…

近端路径特定效应推断AI 解读

Causal mediation analysis has been extended to estimate path-specific effects with multiple intermediate variables, isolating treatment effects through a mediator of interest while excluding pathways through its ancestors. Such analyses address bias from recanting witnesses, i.e., treatment-induced mediator-outcome confounders. However, existing methods typically rely on stringent assumptions precluding general unmeasured confounding, which are often violated in practice. In…

多弱工具变量高维回归的多任务学习AI 解读

Many weak instrumental variables (IVs) are routinely used in the health and social sciences to improve identification and inference of the treatment effect of interest, along with a broad collection of data on potential confounding factors in the hope that the IV assumptions hold within each data stratum. We propose a new debiased continuous-updating generalized method of moments estimator with multi-task learning of the IV propensity scores to simultaneously address the…

利用大量弱交互矩的构造性工具变量识别与推断AI 解读

Instrumental variable methods are widely used for causal inference, but identification becomes especially challenging when instruments are weak and potentially invalid. These challenges are particularly pronounced in Mendelian randomization, where genetic variants serve as instruments and violations of exclusion restriction or independence assumptions are common. We propose MAGIC, a constructive and assumption-lean framework that achieves identification even when all…

稳定隐性混杂与二元结果的准工具变量方法AI 解读

Instrumental variable (IV) methods are central to causal inference from observational data, particularly when a randomized experiment is not feasible. However, of the three conventional core IV identification conditions, only one, IV relevance, is empirically verifiable; often one or both of the other conditions, exclusion restriction and IV independence from unmeasured confounders, are unmet in real-world applications. These challenges are compounded when the outcome is…

GENIUS-MAWII：应对大量弱且无效工具变量的稳健孟德尔随机化AI 解读

Mendelian randomization (MR) has become a popular approach to study causal effects by using genetic variants as instrumental variables. We propose a new MR method, GENIUS-MAWII, which simultaneously addresses the two salient phenomena that adversely affect MR analyses: many weak instruments and widespread horizontal pleiotropy. Similar to MR GENIUS (Tchetgen Tchetgen et al., 2021), we achieve identification of the treatment effect by leveraging heteroscedasticity of the…

含无效工具变量的半参数有效G估计AI 解读

The instrumental variable method is widely used in the health and social sciences for identification and estimation of causal effects in the presence of potentially unmeasured confounding. In order to improve efficiency, multiple instruments are routinely used, leading to concerns about bias due to possible violation of the instrumental variable assumptions. To address this concern, we introduce a new class of g-estimators that are guaranteed to remain consistent and…