Biased estimates of treatment effect in randomized experiments with nonlinear regressions and omitted covariates
随机实验中非线性回归遗漏协变量导致的处理效应估计偏差AI 解读 ↓
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随机实验中非线性回归遗漏协变量导致的处理效应估计偏差AI 解读 ↓
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Certain important nonlinear regression models lead to biased estimates of treatment effect, even in randomized experiments, if needed covariates are omitted. The asymptotic bias is determined both for estimates based on the method of moments and for maximum likelihood estimates. The asymptotic bias from omitting covariates is shown to be zero if the regression of the response variable on treatment and covariates is linear or exponential, and, in regular cases, this is a necessary condition for zero bias. Many commonly used models do have such exponential regressions; thus randomization ensures unbiased treatment estimates in a large number of important nonlinear models. For moderately censored exponential survival data, analysis with the exponential survival model yields less biased estimates of treatment effect than analysis with the proportional hazards model of Cox, if needed covariates are omitted. Simulations confirm that calculations of asymptotic bias are in excellent agreement with the bias observed in experiments of modest size.
在线实验的设计驱动推断:证据收集、检验与估计的联合最优性
Online multifactorial experiments requires early stopping for practically negligible effects while controlling false stopping under continuous monitoring and retaining precise treatment-effect estimation. We develop a design-driven framework that chooses allocation and the evidence rule jointly, treating allocation as evidence collection and testing and estimation as complementary uses of the same evidence. For multifactor experiments with nuisance block effects and…
小样本多协变量随机对照试验中的G计算
In contemporary randomized controlled trials (RCTs), the number of patients is often small relative to the number of baseline covariates collected. In such settings, maximum likelihood estimators of conditional treatment effects in generalized linear models, along with their standard errors, may exhibit substantial bias. This study examines whether similar bias arises in G-computation estimators of marginal treatment effects, which are known for their robustness to model…
广义线性模型中多层模型与固定效应方法的比较
We extend prior work comparing linear multilevel models (MLM) and fixed effect (FE) models to the generalized linear model (GLM) setting, where the coefficient on a treatment variable is of primary interest. This leads to three insights. (i) First, as in the linear setting, MLM can be thought of as a regularized form of FE (RegFE). This explains why group-level confounding can greatly bias MLM's treatment coefficient estimates. However, unlike the linear setting, there is…
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靶向深度生存对比:神经网络下处理特定生存收益的有效推断
Neural survival models are increasingly asked to support counterfactual claims---how much a treatment would change survival in a population---rather than only prognostic risk scores. Answering such questions from observational data requires valid inference for treatment-specific survival contrasts under confounding and covariate-dependent censoring, targets for which standard deep survival estimators are biased and provide no honest uncertainty. We propose Targeted Deep…
诊断测试与人工智能医疗器械的因果评估:效应修饰与信息增强决策
Diagnostic medical tests and devices provide useful information for evaluating the potential benefits and risks of therapeutic treatments. However, unlike treatments, their impact on health outcomes is generally indirect because measuring diagnostic information typically does not itself affect patient outcomes, which complicates evaluation of their effectiveness. In this work, we develop a causal inference approach for evaluating diagnostic tests by distinguishing…