Is the treatment beneficial? Causal Inference with Ordinal Outcomes: A Bayesian Solution
处理是否有益?有序结局因果推断的贝叶斯方法AI 解读 ↓
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处理是否有益?有序结局因果推断的贝叶斯方法AI 解读 ↓
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Randomized experiments with ordinal outcomes are common across scientific applications, but conventional causal estimands such as the average treatment effect are difficult to interpret because ordinal categories lack meaningful numerical spacing. Two interpretable estimands, the probabilities that the treatment is beneficial and strictly beneficial, depend on the joint distribution of the potential outcomes and are therefore not identifiable from observed data. The sharp nonparametric bounds used to circumvent this are often too wide to be informative. We develop a Bayesian latent variable framework that models the join distribution by an ordered probit model and delivers coherent super population and finite population posterior inference on both estimands. The association between the potential outcomes remains non-identified and is treated as a sensitivity parameter. We characterize its impact on the estimands theoretically and empirically, showing a non-monotonic relationship governed by the location of the treatment effect relative to the roots of their partial derivatives and use this to recommend a range for applied use. Simulations show that posterior intervals are narrower than the bounds while retaining near-nominal coverage, a gain that reflects the parametric structure imposed rather than additional information in the data. Application on a rheumatoid arthritis trial shows that the method provides precise and practically relevant assessments of treatment effectiveness.
利用鞅后验推断反事实分布
Causal inference is often focused on average effects, which can hide important aspects of the effect distributions. Here we consider the entire posterior effects distribution by estimating full counterfactual outcome distributions. We propose a methodology for inference on counterfactual distributions which builds upon the martingale posterior framework of Fong et al. (2023). This provides a highly flexible approach to estimating densities, distribution functions, and…
不对可观测数据施加额外限制的灵活观察性研究敏感性分析
A fundamental challenge in observational causal inference is that assumptions about unconfoundedness are not testable from data. Assessing sensitivity to such assumptions is therefore important in practice. Unfortunately, some existing sensitivity analysis approaches inadvertently impose restrictions that are at odds with modern causal inference methods, which emphasize flexible models for observed data. To address this issue, we propose a framework that allows (1) flexible…
利用 SIMEX 估计真实效应量分布
Large-scale online experimentation produces noisy effect estimates, which can overstate gains and complicate decisions about launches and testing policies. We propose a nonparametric method based on SIMulation-EXtrapolation (SIMEX) to estimate the latent distribution of true effects from estimated average treatment effects with known variances. The method evaluates quantiles after adding progressively more simulated measurement noise and extrapolates the resulting inverse…
剩余生存时间分位数的贝叶斯非参数因果推断:阿尔茨海默病应用
In Alzheimer's disease research, a clinically important question is how much longer individuals would remain dementia-free beyond a given time under different baseline amyloid statuses. We address this question using observational data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) treating baseline amyloid status as the exposure. Estimation is challenging because amyloid status is confounded, time to dementia onset is heterogeneous and heavily right censored,…
估计因果分位数效应的贝叶斯半参数方法
Standard causal inference characterizes treatment effect through averages, but the counterfactual distributions could be different in not only the central tendency but also spread and shape. To provide a comprehensive evaluation of treatment effects, we focus on estimating quantile treatment effects (QTEs). Existing methods that invert a nonsmooth estimator of the cumulative distribution functions forbid inference on probability density functions (PDFs), but PDFs can reveal…
BNPqte:用于分位数因果推断的贝叶斯非参数 R 实现
In this article, we introduce the BNPqte R package which implements the Bayesian nonparametric approach of Xu, Daniels and Winterstein (2018) for estimating quantile treatment effects in observational studies. This approach provides flexible modeling of the distributions of potential outcomes, so it is capable of capturing a variety of underlying relationships among the outcomes, treatments and confounders and estimating multiple quantile treatment effects simultaneously.…