Treatment Effect Heterogeneity and Importance Measures for Multivariate Continuous Treatments
多变量连续处理的效应异质性与重要性度量AI 解读 ↓
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多变量连续处理的效应异质性与重要性度量AI 解读 ↓
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Estimating the joint effect of a multivariate, continuous exposure is crucial, particularly in environmental health where interest lies in simultaneously evaluating the impact of multiple environmental pollutants on health. We develop novel methodology that addresses two key issues for estimation of treatment effects of multivariate, continuous exposures. We use nonparametric Bayesian methodology that is flexible to ensure our approach can capture a wide range of data generating processes. Additionally, we allow the effect of the exposures to be heterogeneous with respect to covariates. Treatment effect heterogeneity has not been well explored in the causal inference literature for multivariate, continuous exposures, and therefore we introduce novel estimands that summarize the nature and extent of the heterogeneity, and propose estimation procedures for new estimands related to treatment effect heterogeneity. We provide theoretical support for the proposed models in the form of posterior contraction rates and show that it works well in simulated examples both with and without heterogeneity. Our approach is motivated by a study of the health effects of simultaneous exposure to the components of PM$_{2.5}$, where we find that the negative health effects of exposure to environmental pollutants are exacerbated by low socioeconomic status, race and age.
处理是否有益?有序结局因果推断的贝叶斯方法
Randomized experiments with ordinal outcomes are common across scientific applications, but conventional causal estimands such as the average treatment effect are difficult to interpret because ordinal categories lack meaningful numerical spacing. Two interpretable estimands, the probabilities that the treatment is beneficial and strictly beneficial, depend on the joint distribution of the potential outcomes and are therefore not identifiable from observed data. The sharp…
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Faithfulness is a common assumption in causal inference, often motivated by the fact that the faithful parameters of linear Gaussian and discrete Bayesian networks are typical, and the folklore belief that this should also hold for other classes of Bayesian networks. We address this open question by showing that among all Bayesian networks over a given DAG, the faithful Bayesian networks are indeed `typical': they constitute a dense, open set with respect to the total…
整群随机试验的校准贝叶斯分析
In cluster-randomized trials (CRTs), entire clusters of individuals are randomized to treatment, and outcomes within a cluster are typically correlated. While frequentist approaches are standard practice for CRT analysis, Bayesian methods have emerged as a strong alternative. Previous work has investigated the use of Bayesian hierarchical models for continuous, binary, and count outcomes in CRTs, but these approaches focus on model-based treatment effect coefficients as the…