Size, power and false discovery rates
检验大小、功效与错误发现率AI 解读 ↓
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检验大小、功效与错误发现率AI 解读 ↓
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Modern scientific technology has provided a new class of large-scale simultaneous inference problems, with thousands of hypothesis tests to consider at the same time. Microarrays epitomize this type of technology, but similar situations arise in proteomics, spectroscopy, imaging, and social science surveys. This paper uses false discovery rate methods to carry out both size and power calculations on large-scale problems. A simple empirical Bayes approach allows the false discovery rate (fdr) analysis to proceed with a minimum of frequentist or Bayesian modeling assumptions. Closed-form accuracy formulas are derived for estimated false discovery rates, and used to compare different methodologies: local or tail-area fdr’s, theoretical, permutation, or empirical null hypothesis estimates. Two microarray data sets as well as simulations are used to evaluate the methodology, the power diagnostics showing why nonnull cases might easily fail to appear on a list of “significant” discoveries.
面向超高维数据的贝叶斯单变量引导稀疏回归
Ultra-high-dimensional genomic studies require simultaneous identification of sparse signals, control of spurious discoveries, and computationally feasible inference when the number of predictors can reach hundreds of thousands or more. We propose Bayesian Univariate-Guided Sparse Regression (BUGS), a global--local shrinkage framework that incorporates marginal association information directly into the prior through continuous modulation of shrinkage. By embedding univariate…
通过汤普森采样实现探索驱动的迭代稀疏半定规划聚类
High-dimensional sparse clustering is a challenging combinatorial problem due to the tight coupling between cluster assignment and variable selection. We demonstrate that semidefinite programming (SDP) relaxation of K-means is robust to variable over-selection by establishing minimax separation bounds. Leveraging this robustness, we offer a twist on the recent trend of using exogenous randomness to evaluate feature importance and control false discovery by partially shifting…
准贝叶斯局部投影:同时推断及工具变量扩展
Local projections (LPs) are widely used for impulse response analysis, but Bayesian methods face challenges due to the absence of a likelihood function. Existing approaches rely on pseudo-likelihoods, which often result in poorly calibrated posteriors. We propose a quasi-Bayesian method based on the Laplace-type estimator, where a quasi-likelihood is constructed using a generalized method of moments criterion. This approach avoids strict distributional assumptions, ensures…
高维回归中的差分隐私估计与推断及FDR控制
This paper proposes new methodologies for conducting practical differentially private (DP) estimation and inference in high-dimensional linear regression. We first introduce a DP Bayesian Information Criterion (DP-BIC) for selecting the unknown sparsity parameter in differentially private sparse linear regression (DP-SLR), eliminating the need for prior knowledge of model sparsity, which is a requisite in the existing literature. Next, we develop the DP debiased algorithm…
线性混合因果表征的多域经验贝叶斯学习
Causal representation learning (CRL) aims to learn low-dimensional causal latent variables from high-dimensional observations. While identifiability has been extensively studied for CRL, estimation has been less explored. In this paper, we explore the use of empirical Bayes (EB) to estimate causal representations. In particular, we consider the problem of learning from data from multiple domains, where differences between domains are modeled by interventions in a shared…
AMP框架下基于Lasso统计量的经验贝叶斯变量选择
The Lasso is one of the most ubiquitous methods for variable selection in high-dimensional linear regression and has been studied extensively under different regimes. In a particular asymptotic setup entailing $n/p\to \text{constant}$, an i.i.d.~Gaussian $X$ matrix and linear sparsity, \citet{su2017false} analyzed the Lasso selection path and presented negative results, showing that maintaining small levels of the false discovery proportion comes at a substantial cost in…