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AI 根据所提供的论文材料归类:文本明确比较加权平均处理效应与经典平均处理效应的扩展,并讨论暴露效应异质性。

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Niwen Zhou and Xu Guo’s Contribution to the Discussion of ‘Assumption-Lean Inference for Generalised Linear Model Parameters’ by Vansteelandt and Dukes

周倪文与郭旭对《广义线性模型参数的少假设推断》的讨论

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关注这篇论文的作者
Niwen Zhou
Xu Guo

周倪文与郭旭对《广义线性模型参数的少假设推断》的讨论

研究问题
当暴露效应随协变量变化或工作模型失效时,如何定义仍有条件关联解释的目标量,并理解其与平均处理效应类目标量的关系?
方法与思路
这篇讨论提出相关的新目标量,允许暴露与协变量交互,并讨论模型成立时的平均暴露效应解释;另建议未来向条件分位数扩展。
材料陈述的贡献
讨论摘要称新目标量在允许效应异质性的模型中度量平均暴露效应,模型失效时仍描述条件关联,并说明其与原文目标量的区别。
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应核对讨论中的完整目标量定义、比值与期望的运算顺序、异质性模型条件,以及关联解释转为因果解释是否需要额外假设。
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原文摘要

We thank Professors Vansteelandt and Dukes for their innovative and stimulating paper. They introduce a new estimand which reduces to the exposure effect parameter when the (semi)parametric model holds, is generic for continuous or discrete exposure, and still captures conditional association when model assumption fails. We make some additional understanding of the new estimand and introduce a related new estimand. Here we consider the expectation of the ratio. Here β· and ω· are unknown functions. Different from the model (4) in Vansteelandt and Dukes (2021), we now allow A–L interaction, and extend to the exposure effect heterogeneity setting, with respect to L. While under model (1), γ=Eβ(L)⁠, which measures the average exposure effect. When there is no exposure effect heterogeneity, i.e. β(L)≡β⁠, γ reduces to β as the estimand in Vansteelandt and Dukes (2021). Even when the model fails, the estimand γ is still meaningful to capture conditional association. Clearly, the new estimand in Vansteelandt and Dukes (2021) can be viewed as an extension of weighted average treatment effect; while our new estimand is an extension of the classical average treatment effect. Lastly, current literature only focus on the conditional expectation of the exposures, which is sensitive to outliers. Conditional quantile can provide a more robust and complete view of the association between response and exposure. Thus it would be very interesting to extend the insightful idea in Vansteelandt and Dukes (2021) to quantile setting.

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