One-step TMLE for weighted average treatment effects
加权平均处理效应的一步目标最大似然估计AI 解读 ↓
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AI 根据所提供的论文材料归类:摘要直接研究平均处理效应、已处理人群效应及重叠目标的 TMLE 与因果估计效率。
加权平均处理效应的一步目标最大似然估计AI 解读 ↓
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We consider Targeted Maximum Likelihood Estimation (TMLE) of weighted average treatment effects (WATEs), a class of causal estimands that reweight the covariate distribution using a specified function of the propensity score. This class includes the average treatment effect and average treatment effect on the treated, as well as various overlap-based targets. We provide a comprehensive analysis of the one-step TMLE along the universal least favorable path for such parameters. Under explicit regularity conditions on the weight function and initialization, we show that the targeting procedure is well-defined, reaches a solution of the estimating equation in finite time, and yields an asymptotically efficient estimator. In particular, convergence of the targeting dynamics and control of the second-order remainder are derived from these conditions rather than imposed as separate assumptions on the output of the algorithm.
TMLE 与 AIPW 中样本分割选择何时重要:交叉拟合、目标化与重复
Variants of targeted maximum likelihood estimation (TMLE) and augmented inverse-probability weighting (AIPW) with machine-learning nuisance models differ in which observations train them, how bias is corrected, and whether splits are repeated. In known-truth simulations of a binary-outcome average treatment effect, eight headline estimators shared each setting's library, inner folds and truncation bound; coverage differences were judged against a prespecified…
在线实验的设计驱动推断:证据收集、检验与估计的联合最优性
Online multifactorial experiments requires early stopping for practically negligible effects while controlling false stopping under continuous monitoring and retaining precise treatment-effect estimation. We develop a design-driven framework that chooses allocation and the evidence rule jointly, treating allocation as evidence collection and testing and estimation as complementary uses of the same evidence. For multifactor experiments with nuisance block effects and…
小样本多协变量随机对照试验中的G计算
In contemporary randomized controlled trials (RCTs), the number of patients is often small relative to the number of baseline covariates collected. In such settings, maximum likelihood estimators of conditional treatment effects in generalized linear models, along with their standard errors, may exhibit substantial bias. This study examines whether similar bias arises in G-computation estimators of marginal treatment effects, which are known for their robustness to model…
广义线性模型中多层模型与固定效应方法的比较
We extend prior work comparing linear multilevel models (MLM) and fixed effect (FE) models to the generalized linear model (GLM) setting, where the coefficient on a treatment variable is of primary interest. This leads to three insights. (i) First, as in the linear setting, MLM can be thought of as a regularized form of FE (RegFE). This explains why group-level confounding can greatly bias MLM's treatment coefficient estimates. However, unlike the linear setting, there is…
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Exploiting the equality restrictions that nested Markov models encode requires their tangent-space geometry. For strictly positive finite-state models on arbitrary acyclic directed mixed graphs (ADMGs), we differentiate the recursive-head chart and prove that the range of its score map is the full tangent space. Intrinsic-set coordinate blocks form an algebraic direct sum, blocks of distinct districts are orthogonal, and the resulting Gram projection needs neither…
靶向深度生存对比:神经网络下处理特定生存收益的有效推断
Neural survival models are increasingly asked to support counterfactual claims---how much a treatment would change survival in a population---rather than only prognostic risk scores. Answering such questions from observational data requires valid inference for treatment-specific survival contrasts under confounding and covariate-dependent censoring, targets for which standard deep survival estimators are biased and provide no honest uncertainty. We propose Targeted Deep…