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结合感染调查与病例计数辅助信息估计奥地利新冠感染率

研究问题
病例计数存在参与偏差时,如何将其与感染调查中的登记状态联合使用,提高总体感染率估计效率并推算病例发现率?
方法与思路
作者结合奥地利感染调查结果与病例计数辅助信息,构造感染率估计及置信区间,并处理检测灵敏度、特异度及调查加权。
材料陈述的贡献
摘要称联合方法提高估计效率,使较小调查样本达到同等估计精度;估计量与置信区间已实现于配套 R 包 pempi。
阅读关注点
应核对调查与病例登记的链接方式、参与偏差如何进入估计、检测误差参数的来源,以及加权和辅助信息带来的方差变化。
阅读边界
仅据 OpenAlex 索引摘要,稿件版本未注明;效率增益数值、误差参数不确定性和外推条件未说明,不能推断刊本变化。

原文摘要

Countries officially record the number of COVID-19 cases based on medical tests of a subset of the population. These case count data obviously suffer from participation bias, and for prevalence estimation, these data are typically discarded in favour of infection surveys, or possibly also completed with auxiliary information. One exception is the series of infection surveys recorded by the Statistics Austria Federal Institute to study the prevalence of COVID-19 in Austria in April, May and November 2020. In these infection surveys, participants were additionally asked if they were simultaneously recorded as COVID-19 positive in the case count data. In this paper, we analyze the benefits of properly combining the outcomes from the infection survey with the case count data, to analyze the prevalence of COVID-19 in Austria in 2020, from which the case ascertainment rate can be deduced. The results show that our approach leads to a significant efficiency gain. Indeed, considerably smaller infection survey samples suffice to obtain the same level of estimation accuracy. Our estimation method can also handle measurement errors due to the sensitivity and specificity of medical testing devices and to the nonrandom sample weighting scheme of the infection survey. The proposed estimators and associated confidence intervals are implemented in the companion open source R package pempi available on the Comprehensive R Archive Network (CRAN).

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