Variable importance measures for heterogeneous treatment effects
异质性处理效应的变量重要性度量AI 解读 ↓
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异质性处理效应的变量重要性度量AI 解读 ↓
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Motivated by applications in precision medicine and treatment effect heterogeneity, recent research has focused on estimating conditional average treatment effects (CATEs) using machine learning (ML). CATE estimates may represent complicated functions that provide little insight into the key drivers of heterogeneity. Therefore, we introduce nonparametric treatment effect variable importance measures (TE-VIMs), based on the mean-squared error (MSE) in predicting the individual treatment effect. More precisely, TE-VIMs represent the increase in MSE when variables are removed from the CATE conditioning set. We derive efficient TE-VIM estimators which can be used with any CATE estimation strategy and are amenable to ML estimation. We propose several strategies to calculate these VIMs (e.g. leave-one out, or keep-one in), using popular meta-learners for the CATE. We study the finite sample performance through a simulation study and illustrate their application using clinical trial data.
条件影响函数
There are many nonparametric objects of interest that are functionals of a conditional distribution, such as average treatment effects conditional on a low-dimensional set of covariates. We define a conditional influence function (CIF) as the Gateaux derivative of a conditional parameter with respect to perturbations of the conditional law of a single observation given the conditioning variable. CIFs generalize classical influence functions and can be used to (i) construct…
图分割贝叶斯因果森林:空间异质性处理效应估计
In spatial observational studies, treatment assignment and outcomes often exhibit spatial dependence patterns, and treatment effects may vary across space and subpopulations due to both measured and unmeasured spatially structured confounders. Accounting for spatial dependence while estimating heterogeneous treatment effects (HTEs) is a central task in spatial causal inference. Causal Bayesian additive regression tree methods are popular nonparametric methods for modeling…
树方法中的核平衡
Studying heterogeneous treatment effects has become essential in experimental and observational studies. A critical assumption for obtaining reliable treatment effect estimates is overlap, which requires that treated and control units have sufficiently similar covariate distributions. Poor overlap may limit the effectiveness of estimators, especially those based on propensity scores, potentially leading to unreliable results. We investigate the effectiveness of kernel…
结合负向控制的因果生存森林
We study heterogeneous treatment-effect (HTE) estimation in observational survival studies commonly associated with both censored outcomes and unmeasured confounding. We integrate causal survival forests (CSF) with negative controls (NC) from proximal causal inference and introduce Negative Control Causal Survival Forests (NC-CSF), a flexible nonparametric HTE learner for survival analysis. Our approach uses a loss that incorporates proxy variables and Neyman…
鞅 R 学习器:事件时间结果的时变异质性治疗效应估计
Biological research and clinical evidence suggest that treatment response may vary substantially along characteristics, such as comorbidities, genetic variants, environmental, or socio-economic factors. Future precision medicine requires accurate assessment of heterogeneous treatment effects (HTE) to guide optimal clinical decisions at the individual level. We introduce a functional score framework that extends the traditional estimating equations for survival data to…
利用因果森林估计出行方式转变的异质性
Objectives: While causal analysis of travel behavior is an emerging field, estimating heterogeneity in mode choice through causal modeling remains unexplored. This study demonstrates the application of a novel causal method, causal forest, to quantify the heterogeneity in travel mode choice shifts caused by the COVID-19 pandemic. Methods: We applied causal forests, a non-parametric causal machine learning method, to 802,935 trip records from the 2017 and 2022 waves of the…