Optimal Experimental Designs When Some Independent Variables Are Not Subject to Control
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This article considers the problem of constructing optimal designs for regression models when the design space is a product space and some of the variables are not under the control of the practitioner. A variable that is not under control can have known values before the experiment is performed or else unknown values before the experiment is realized. The first case is briefly discussed in the literature. The aim of this work is to provide equivalence theorems for the second case and the mixture of both cases. Iterative algorithms for generating approximate optimal designs are given, and a real case of lung cancer is discussed.