Sequential Analysis of Binomial Clinical Trials

We examine results produced by a new likelihood stopping rule for terminating clinical trials, designed to choose the better of two competing dichotomous treatmente, or to decide that they are equal. A method for adaptive assignment is also discussed, for the purpose of reducing the number of tests with the poorer treatment. A comparison of results with several alternative designs given in the literature shows that the proposed design either gives substantial improvement over them or equals their performance except in the case of competing treatments with high success probabilities. The procedures studied assume that response to treatment is immediate.

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