Generalization error bounds of dynamic treatment regimes in penalized regression-based learning
惩罚回归学习动态治疗方案的泛化误差界AI 解读 ↓
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AI 根据所提供的论文材料归类:摘要直接研究干预规则实施后的预期结局及动态治疗方案价值,与因果推断中的治疗决策直接相关。
惩罚回归学习动态治疗方案的泛化误差界AI 解读 ↓
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A dynamic treatment regime (DTR) is a sequence of decision rules, one per stage of intervention, that maps up-to-date patient information to a recommended treatment. Discovering an appropriate DTR for a given disease is a challenging issue especially when a large set of prognostic variables are observed. To address this problem, we propose penalized regression-based learning methods with l1 penalty to estimate the optimal DTR that would maximize the expected outcome if implemented. We also provide generalization error bounds of the estimated DTR in the setting of finite number of stages with multiple treatment options. We first examine the relationship between value and Q-functions and derive a finite sample upper bound on the difference in values between the optimal and the estimated DTRs. For practical implementation, we develop an algorithm with partial regularization via orthogonality to construct the optimal DTR. The advantages of the proposed methods are demonstrated with extensive simulation studies and data analysis of depression clinical trials.