Semiparametric Stochastic Mixed Models for Longitudinal Data
纵向数据的半参数随机混合模型AI 解读 ↓
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纵向数据的半参数随机混合模型AI 解读 ↓
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We consider inference for a semiparametric stochastic mixed model for longitudinal data. This model uses parametric fixed effects to represent the covariate effects and an arbitrary smooth function to model the time effect and accounts for the within-subject correlation using random effects and a stationary or nonstationary stochastic process. We derive maximum penalized likelihood estimators of the regression coefficients and the nonparametric function. The resulting estimator of the nonparametric function is a smoothing spline. We propose and compare frequentist inference and Bayesian inference on these model components. We use restricted maximum likelihood to estimate the smoothing parameter and the variance components simultaneously. We show that estimation of all model components of interest can proceed by fitting a modified linear mixed model. We illustrate the proposed method by analyzing a hormone dataset and evaluate its performance through simulations.
半参数非线性混合效应模型及其应用
Nonlinear mixed effects models (NLMMs) and self-modeling nonlinear regression (SEMOR) models are often used to fit repeated measures data. They use a common function shared by all subjects to model variation within each subject and some fixed and/or random parameters to model variation between subjects. The parametric NLMM may be too restrictive, and the semiparametric SEMOR model ignores correlations within each subject. In this article we propose a class of semiparametric…
经验贝叶斯棒球再论:纵向数据的经验贝叶斯方法
Summary Empirical Bayes methods for Gaussian and binomial compound decision problems involving longitudinal data are considered. A recent convex optimization reformulation of the nonparametric maximum likelihood estimator of Kiefer and Wolfowitz ( Annals of Mathematical Statistics 1956; 27 : 887–906) is employed to construct nonparametric Bayes rules for compound decisions. The methods are illustrated with an application to predict baseball batting averages, and the age…
混合效应平滑样条方差分析
Summary We propose a general family of nonparametric mixed effects models. Smoothing splines are used to model the fixed effects and are estimated by maximizing the penalized likelihood function. The random effects are generic and are modelled parametrically by assuming that the covariance function depends on a parsimonious set of parameters. These parameters and the smoothing parameter are estimated simultaneously by the generalized maximum likelihood method. We derive a…
使用 mgcv 估计半参数与非参数固定效应面板模型
This paper provides a practical guide to estimating semiparametric and nonparametric fixed-effects panel data models using the mgcv package in R. The focus is implementation: handling fixed effects with unit indicators, first differencing, or penalized unit effects; specifying smooth terms; and conducting cluster-robust inference. Monte Carlo experiments compare \code{mgcv::bam} estimators with linear and fixed-series spline estimators. Simulations suggest that penalized…
异质性、不确定性与学习:半参数识别和估计
We provide identification results for a broad class of learning models in which continuous outcomes depend on three types of unobservables: known heterogeneity, initially unknown heterogeneity that may be revealed over time, and transitory uncertainty. We consider a common environment where the researcher only has access to a short panel on choices and realized outcomes. We establish identification of the outcome equation parameters and the distribution of the unobservables,…
多变量纵向与生存数据的半参数潜在类别模型
In long-term follow-up studies, data are often collected on repeated measures of multivariate response variables as well as on time to the occurrence of a certain event. To jointly analyze such longitudinal data and survival time, we propose a general class of semiparametric latent-class models that accommodates a heterogeneous study population with flexible dependence structures between the longitudinal and survival outcomes. We combine nonparametric maximum likelihood…