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分类依据与纠错

AI 根据所提供的论文材料归类:摘要研究一般混合模型的错设稳健选择,使用因果结构知识不足以归为处理效应或其他所列方向。

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关注这篇论文的作者
Jiawei Li

考虑结构信息的稳健混合模型选择

研究问题
混合模型的观测分布错设时,如何避免样本增大后用虚假子群补偿模型误差,并稳定识别具有实际含义的子群数量?
方法与思路
作者结合已知因果结构与对观测模型误差程度的粗略认识,构造新的混合模型选择准则,以提高子群发现对模型错设的稳健性。
材料陈述的贡献
摘要称在所述假设下证明一致性,并通过模拟和流式细胞术应用展示正确子群数量的识别,支持利用结构知识开展模型选择。
阅读关注点
应核对因果结构和错设程度如何进入准则、一致性的具体对象与假设,以及专家标注不足或误差判断失准时的表现。
阅读边界
这是 arXiv 预印本,未核实同行评审或期刊接收。摘要未列出一致性条件和错设范围,不能认为任意混合模型误差都可稳健处理。

原文摘要

Mixture models are often used to identify meaningful subpopulations (i.e., clusters) in observed data such that the subpopulations have a real-world interpretation (e.g., as cell types). However, when used for subpopulation discovery, mixture model inference is usually ill-defined a priori because the assumed observation model is only an approximation to the true data-generating process. Thus, as the number of observations increases, rather than obtaining better inferences, the opposite occurs: the data is explained by adding spurious subpopulations that compensate for the shortcomings of the observation model. However, there are two important sources of prior knowledge that we can exploit to obtain well-defined results no matter the dataset size: known causal structure (e.g., knowing that the latent subpopulations cause the observed signal but not vice-versa) and a rough sense of how wrong the observation model is (e.g., based on small amounts of expert-labeled data or some understanding of the data-generating process). We propose a new model selection criteria that, while model-based, uses this available knowledge to obtain mixture model inferences that are robust to misspecification of the observation model. We provide theoretical support for our approach by proving a first-of-its-kind consistency result under intuitive assumptions. Simulation studies and an application to flow cytometry data demonstrate our model selection criteria consistently finds the correct number of subpopulations.

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